333303-58-5

Upstream product

• 101376-74-3 (E)-4-(benzyloxy)-2-methylbut-2-enal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 261775-38-6 6-benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-4-methyl-hex-4-en-3-ol 

Downstream Products

• 333303-59-6 (2S,3S,4R)-1-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3-methyl-hexane-2,4-diol 
• 333303-62-1 (E)-3-{(4R,5S,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-acrylic acid ethyl ester 
• 333303-60-9 [2-((4R,5S,6S)-6-Benzyloxymethyl-2,2,5-trimethyl-[1,3]dioxan-4-yl)-ethoxy]-tert-butyl-diphenyl-silane 
• 333303-63-2 tert-Butyl-diphenyl-{2-[(4R,5S,6R)-2,2,5-trimethyl-6-((E)-propenyl)-[1,3]dioxan-4-yl]-ethoxy}-silane 
• 333303-61-0 (4S,5S,6R)-6-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2,2,5-trimethyl-[1,3]dioxane-4-carbaldehyde 

Relevant academic research and scientific papers

Synthesis of chiral 1,3-diols by radical-mediated regioselective opening of 2,3-epoxy alcohols using cp2TiCl

Radical-mediated opening of chiral 2,3-epoxy alcohols 1a-e, regioselectively at the 2-position, using cp2TiCl in the absence of a hydrogen source leads to the formation of the 1,3-diols 2a-e.

Diastereoselective opening of trisubstituted epoxy alcohols: Application in the synthesis of (+)-prelactone C

A novel method developed by us for the synthesis of chiral 2-methyl-1,3-diols by radical-mediated diastereoselective opening of trisubstituted epoxy alcohols at the more substituted carbon was the key step in the synthesis of (+)-prelactone C (1).