333319-62-3

Usage

Compound Formation

1-Phenylethylamine oxalamic acid ethyl ester is a compound formed by the reaction of 1-phenylethylamine with oxalamic acid and ethyl ester.

Uses

It is used as a precursor in the synthesis of various organic compounds and pharmaceuticals.

Potential Applications

It has potential applications in medicinal chemistry and drug development due to its diverse reactivity and functional groups.

Building Block

It may be used as a building block in the synthesis of other complex molecules.

Starting Material

It can serve as a starting material for the production of new chemical entities with potential therapeutic properties.

Unique Structure

Its unique structure and chemical properties make it a valuable intermediate in organic synthesis and medicinal research.

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 618-36-0 rac-methylbenzylamine 
• 98-85-1 1-Phenylethanol 
• 216959-44-3 [tert-butoxycarbonyl-(1-phenyl-ethyl)-amino]-oxo-acetic acid ethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 6170-91-8 N-<1-Phenyl-ethyl>-N'-p-toluolsulfonyl-oxalsaeurediamid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 164219-32-3 (S)-2-oxo-2-((1-phenylethyl)amino)acetic acid 
• 185527-09-7 (R)-N-(1-phenylethyl)oxalamic acid 
• 164219-31-2 ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate 
• 102548-99-2 1-methyl-4,4-diphenyl-1,4-dihydro-2H-isoquinolin-3-one 

Relevant academic research and scientific papers

Visible-light mediated carbamoyl radical addition to heteroarenes

The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization.

2,2,2-Trifluoroethyl Oxalates in the One-Pot Parallel Synthesis of Hindered Aliphatic Oxamides

A simple parallel synthesis approach to unsymmetrical N1,N2-substituted aliphatic oxamides using methyl (2,2,2-trifluoroethyl) oxalate and bis(2,2,2-trifluoroethyl) oxalate was developed. The method was validated on a 52-membered set of the oxamides, derived mainly from hindered primary and secondary aliphatic amines, and gave the products with a high overall success rate in moderate yields.

N-Boc ethyl oxamate: A new nitrogen nucleophile for use in Mitsunobu reactions

N-Boc ethyl oxamate can be directly coupled with primary and secondary alcohols under Mitsunobu conditions to afford various N-Boc mines after mild deprotection.

Enantiomerically pure amines by a new method: Biotransformation of oxalamic esters using the lipase from Candida antarctica

Octyl oxalamic esters of 1-phenylethylamine and substituted 1-phenylethylamines are kinetically resolved with high stereoselectivity by lipase B from Candida antarctica.