333335-31-2

Upstream product

• 333335-39-0 tert-Butyl-[(S)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-(toluene-4-sulfonyl)-propoxy]-diphenyl-silane 
• 333335-30-1 (2S,3S)-3-(tert-Butyl-diphenyl-silanyloxy)-5-(toluene-4-sulfonyl)-pentane-1,2-diol 
• 333335-38-9 Benzoic acid (1S,2S)-2,3-dihydroxy-1-[2-(toluene-4-sulfonyl)-ethyl]-propyl ester 
• 333335-29-8 (S)-1-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-3-(toluene-4-sulfonyl)-propan-1-ol 
• 333335-27-6 (E)-5-(Toluene-4-sulfonyl)-pent-2-enoic acid ethyl ester 
• 333335-28-7 {(2R,3R)-3-[2-(Toluene-4-sulfonyl)-ethyl]-oxiranyl}-methanol 
• 333335-37-8 (E)-5-(Toluene-4-sulfonyl)-pent-2-en-1-ol 
• 63305-65-7 3-((4-methylphenyl)sulfonyl)propanal 
• 69739-34-0 t-butyldimethylsiyl triflate 

Downstream Products

• 333335-32-3 4-(tert-butyl-dimethyl-silanyloxy)-6-[1-(tert-butyl-diphenyl-silanyloxy)-3-(toluene-4-sulfonyl)-propyl]-2-(dimethyl-[1,3]dioxolan-4-yl)-3,6-dihydro-2H-pyran 

Relevant academic research and scientific papers

Enantioselective synthesis of a tetrasubstituted oxocane via a double diastereoselective hetero Diels-Alder reaction

A procedure for the enantioselective preparation of tetra-substituted medium sized cyclic ethers is presented. An oxocane is prepared by a sequence which involves a double diastereoselective hetero Diels-Alder reaction between a chiral aldehyde and a diene bearing an allylic chiral centre. The cycloadduct is transformed into a linear ether which is then converted to the cyclic ether by a highly regioselective intramolecular alkylation of a lithiosulfone with an epoxide. The sense of induction of the chiral centre on the diene is discussed.