333346-57-9Relevant academic research and scientific papers
2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
Rasina, Dace,Stakanovs, Georgijs,Borysov, Oleksandr V.,Pantelejevs, Teodors,Bobrovs, Raitis,Kanepe-Lapsa, Iveta,Tars, Kaspars,Jaudzems, Kristaps,Jirgensons, Aigars
, p. 2488 - 2500 (2018)
2-Aminoquinazolin-4(3H)-ones were previously discovered as perspective leads for antimalarial drug development targeting the plasmepsins. Here we report the lead optimization studies with the aim to reduce inhibitor lipophilicity and increase selectivity
