333347-98-1Relevant academic research and scientific papers
Expedient synthesis of xanthones and multi-functionalized chromones from 1,1-diacyl cyclopropanes
French, Sarah A.,Clark, Mitchell R.,Smith, Robert J.,Brind, Thomasin,Hawkins, Bill C.
, p. 5340 - 5350 (2018)
We report the rapid synthesis of various cycloheptane-fused chromones and an oxepine fused flavone in 5 steps from the corresponding 2-hydroxy acetophenone. Furthermore, we describe the synthesis of xanthones, in moderate to good yield, from 2,3-disubstit
Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N -Acylbenzotriazoles under Mild Reaction Conditions
Singh, Mala,Singh, Anoop S.,Mishra, Nidhi,Agrahari, Anand K.,Tiwari, Vinod K.
, p. 2183 - 2190 (2019/05/10)
N -Acylbenzotriazoles are achieved in good yields from the corresponding carboxylic acids by using only 0.35 equivalent of trichloroisocyanuric acid and 1.2 equivalents of PPh 3. The salient features of the developed reaction path include an ec
Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase
Fu, Jie,Yang, Ying,Zhang, Xue-Wei,Mao, Wen-Jun,Zhang, Zhi-Ming,Zhu, Hai-Liang
experimental part, p. 8457 - 8462 (2011/02/26)
Twenty-one benzotriazoles (3-16 and 18-24) were synthesized and half of them (5, 8-16, 20, and 21) were reported for the first time. Their antiproliferative activities against three human cancer cells were assayed. It revealed that 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate (9) showed considerable activity against three human cancer cell lines with the half maximal inhibitory concentration (IC50) values of 1.2-2.4 nM, which were close to the value of the positive control, doxorubicin. Further investigation indicated compound 9 was a potential histone deacetylase inhibitor (IC50 = 9.4 μM) and its binding mode was simulated using docking method.
