333354-55-5Relevant academic research and scientific papers
Analogs of 4-hydroxyisoleucine and uses thereof
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Page/Page column 42, (2008/06/13)
The invention relates to analogs of 4-hydroxyisoleucine, and to lactones, pharmaceutically acceptable salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. The analogs of the invention stimulate both glucose uptake and insulin secretion, and may thus be useful for the prevention and treatment of disorders of carbohydrate or lipid metabolism, including diabetes mellitus (type 1 and type 2 diabetes), pre-diabetes, and Metabolic Syndrome.
Stereocontrolled synthesis of (2S*,3R*,4R*)-4-hydroxy-3-methylproline using a silicon assisted aza-[2,3]-Wittig sigmatropic rearrangement
Anderson, James C.,Flaherty, Alice
, p. 267 - 269 (2007/10/03)
Racemic synthesis of the non-proteinogenic amino acid (2S,3R,4R)-4-hydroxy-3-methylproline was discussed. Iodolactonization of an unstarurated amino acid derivative was done. Results showed that the silicon assisted aza-[2,3]-Wittig sigmatropic rearrangem
