333382-86-8Relevant academic research and scientific papers
Solvent-assisted organized structures based on amphiphilic anion-responsive π-conjugated systems
Maeda, Hiromitsu,Ito, Yoshihiro,Haketa, Yohei,Eifuku, Nazuki,Lee, Eunji,Lee, Myongsoo,Hashishin, Takeshi,Kaneko, Kenji
, p. 3706 - 3719 (2009)
synthesis of amphiphilic π-conjugated acyclic oligopyrroles and the formation of solvent-assisted aggregates are reported. We have prepared various types of BF2 complexes of 1,3-dipyrrolylpropane-1,3-diones bearing aryl rings substituted with h
POLYCYCLIC COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES
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Paragraph 1507; 1508, (2020/03/29)
The present disclosure relates to bifunctional compounds, ULM— L—PTM, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A- RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.
Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers
Banerjee, Ashutosh,Maschauer, Simone,Hübner, Harald,Gmeiner, Peter,Prante, Olaf
, p. 6079 - 6082 (2013/11/06)
Taking advantage of click chemistry, a library of N-arylpiperazinylmethyl triazoles bearing fluoro substituted appendages was synthesized and the target compounds were investigated for dopamine and serotonin receptor binding. With the aim to bias their hydrophilicity and to optimize their D4 receptor affinity and selectivity, a concise series of triazoles containing fluoroalkyl, fluoroalkoxy, fluoroalkoxyphenyl, and deoxyfluoroglucosyl substituents was studied. The D4 receptor affinity and selectivity could be tuned by altering the chemical moiety attached to the triazole unit. Among the test compounds, the fluoroethoxyphenyl derivative 15b showed weak partial agonism at D4 and a K i value of 14 nM, while its fluoropropoxyphenyl homologue 16a turned out to act as a neutral D4 antagonist (Ki = 5.1 nM). Both, 15b and 16a revealed an excellent balance between D4 receptor affinity and subtype selectivity, providing lead candidates for the development of 18F-labeled radioligands for D4 receptor imaging studies by positron emission tomography (PET).
Photoswitchable rotaxanes using the photolysis of alkoxyacridanes
Abraham, Werner,Wlosnewski, Andre,Buck, Karin,Jacob, Sabine
supporting information; experimental part, p. 142 - 154 (2009/04/07)
9-Aryl-9-alkoxy-acridanes and their counterparts, 9-aryl-acridinium ions, have been incorporated into the axles both of one- and two-station [2]rotaxanes. The ring component of the rotaxanes consists of the tetracationic ring cyclobis(paraquat-4,4′-bisphe
Synthesis of pyridinocrownophanes exhibiting high Ag+-affinity
Inokuma, Seiichi,Kimura, Koichi,Funaki, Takashi,Nishimura, Jun
, p. 123 - 130 (2007/10/03)
Crownophanes possessing a pyridine moiety were prepared by means of intramolecular [2 + 2] photocycloaddition of the styrene derivatives. The crown compounds having six to ten ethereal oxygens selectively extracted Ag+ with high efficiency in the liquid-liquid extraction. The high extractability and efficiency were maintained even at low pH region of the extraction system. From ESI-MS analysis, it was found that the crownophanes formed some kinds of complexes having 1:1 and 2:1 stoichiometry (host/guest) with Ag+ and Pb2+ in MeCN-H2O homogeneous system.
SELECTIV BROMINATION OF THE AROMATIC RING IN ω-PHENYLPOLYOXAALKANES AND ALKANOLS IN MICELLES
Jursic, Branko
, p. 1553 - 1558 (2007/10/02)
The regioselecticity of bromination of ω-phenylpolyoxaalkanes and alkanols by bromine in aqueous solution of dodecyl sulfate (SDS) and aqueous solution of cetyltrimethylammonium bromide (CTAB) are shown to be related to the average orientation of substrate as indicated by 1H NMR studies.Thus ortho-bromination is promoted at higher concentrations of the surfactant relative to pure water.In contrast, at an equal ratio of the surfactant and substrate para-bromination is promoted.The results are discussed with respect to the average orientation of substrate in a micellar microenvironment and the formation of an ether-bromine comples as possible bromination agent.
