333385-26-5Relevant academic research and scientific papers
Total Synthesis and Determination of the Absolute Configuration of Frondosin B
Masayuki, Inoue,Carson, Mattew W.,Frontier, Alison J.,Danishefsky, Samuel J.
, p. 1878 - 1889 (2007/10/03)
Two concise syntheses of (+/-)-frondosin B (1), an interleukin-8 receptor antagonist, have been achieved from commercially available 5-methoxysalicylaldehyde. The seven-membered ring in ketone 33, the common intermediate for both syntheses, was built by a
The total synthesis of frondosin B
Inoue, Masayuki,Frontier, Alison J.,Danishefsky, Samuel J.
, p. 761 - 764 (2007/10/03)
The interleukin-8 receptor antagonist frondosin B (1) was synthesized in 12 steps from commercially available 5-methoxysalicylaldehyde in a completely regiocontrolled manner. The key steps of the synthesis were a Friedel-Crafts reaction to form the 7-memb
