333401-64-2

Upstream product

• 34582-29-1 1-(tert-butyl)-2,3-dimethoxy-5-methylbenzene 
• 333401-61-9 5-bromomethyl-3-tert-butyl-1,2-dimethoxybenzene 
• 333401-62-0 5-tert-butyl-3,4-dimethoxybenzyl alcohol 
• 203984-66-1 2-bromo-5-(tert-butyl)-3,4-dimethoxy-1-methylbenzene 
• 333401-63-1 5-tert-butyl-3,4-dimethoxybenzaldehyde 

Downstream Products

• 333401-66-4 4,5'-di-tert-butyl-6-methyl-2,3,3',4'-tetramethoxy-diphenylmethane 

Relevant academic research and scientific papers

First total synthesis of the mastigophorenes C and D and of simplified unnatural analogs

The first total synthesis of the mastigophorenes C (2) and D (3), natural 'dimeric' sesquiterpenes isolated from the liverwort Mastigophora diclados with interesting biological activities, is described. As previously for mastigophorenes A (1) and B, the divergent synthetic approach was first optimized on a simplified model system with a tert-butyl group instead of the chiral cyclopentyl residue, also in order to find more easily available compounds with similar or even improved biological activity.