33342-67-5

Usage

Uses

Used in Pharmaceutical Research:
2-(Phenylthio)thiazole is used as a key intermediate in the synthesis of biologically active molecules for pharmaceutical research. Its presence in these molecules contributes to their antimicrobial, antitumor, and anti-inflammatory properties, which are crucial for the development of new drugs to treat a range of diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(Phenylthio)thiazole is employed as a versatile building block. Its chemical reactivity and structural features make it a valuable component in the creation of complex organic compounds, which can be further utilized in various chemical and pharmaceutical applications.
Used in Drug Development:
2-(Phenylthio)thiazole is used as a potential candidate in drug development, particularly for the treatment of diseases that require antimicrobial, antitumor, or anti-inflammatory interventions. Its pharmacological activities suggest that it could be a promising starting point for the design of new therapeutic agents.
Used in Antimicrobial Applications:
2-(Phenylthio)thiazole is used as an antimicrobial agent, leveraging its ability to inhibit the growth of various microorganisms. This makes it a valuable component in the development of new antibiotics and antimicrobial treatments.
Used in Anti-inflammatory Applications:
2-(Phenylthio)thiazole is used as an anti-inflammatory agent, helping to reduce inflammation and associated symptoms. Its potential in this area could lead to the development of new treatments for inflammatory conditions.
Used in Antitumor Applications:
2-(Phenylthio)thiazole is used as an antitumor agent, with potential applications in cancer therapy. Its ability to interfere with tumor growth and progression makes it a candidate for further research and development in oncology.

Upstream product

• 3034-53-5 2-bromo-1,3-thiazole 
• 108-98-5 thiophenol 
• 1212-08-4 S-Phenyl benzenethiosulfonate 
• 3034-52-4 2-chlorothiazole 
• 288-47-1 1,3-thiazole 
• 882-33-7 diphenyldisulfane 
• 591-50-4 iodobenzene 

Downstream Products

• 1195901-16-6 4-(2-phenylsulfanyl-thiazol-5-yl)-morpholine 
• 1195901-17-7 1-methyl-4-[2-(phenylthio)-1,3-thiazol-5-yl]piperazine 
• 1245530-68-0 5-(1,1,1,3,3,3-hexamethyldisilazan-2-yl)-2-phenylsulfanylthiazole 
• 1319212-47-9 C₁₂H₁₅NS₂Si 
• 33342-71-1 5-chloro-2-phenylsulfanyl-thiazole 
• 1319212-59-3 C₂₁H₂₃NO₂S₂Si 
• 1319212-60-6 C₁₉H₁₉NOS₂Si 
• 1319212-62-8 C₁₈H₁₄ClNO₂S₂ 
• 1319212-64-0 C₁₈H₁₅NO₂S₂ 
• 1319212-65-1 C₁₆H₁₀INOS₂ 
• 1319212-66-2 C₁₈H₁₄INO₂S₂ 
• 1319212-51-5 C₂₃H₁₅NO₂S₂ 
• 1319212-52-6 C₂₃H₁₅N₃S₂ 
• 1319212-49-1 C₁₆H₁₃NOS₂ 

Relevant academic research and scientific papers

Thioetherification of Chloroheteroarenes: A Binuclear Catalyst Promotes Wide Scope and High Functional-Group Tolerance

A constrained binuclear palladium catalyst system affords selective thioetherification of a wide range of functionalized arenethiols with chloroheteroaromatic partners with the highest turnover numbers (TONs) reported to date and tolerates a large variety of reactive functions. The scope of this system includes the coupling of thiophenols with six- and five-membered 2-chloroheteroarenes (i.e., functionalized pyridine, pyrazine, quinoline, pyrimidine, furane, and thiazole) and 3-bromoheteroarenes (i.e., pyridine and furane). Electron-rich congested thiophenols and fluorinated thiophenols are also suitable partners. The coupling of unprotected amino-2-chloropyridines with thiophenol and the successful employment of synthetically valuable chlorothiophenols are described with the same catalyst system. DFT studies attribute the high performance of this binuclear palladium catalyst to the decreased stability of thiolate-containing resting states. Palladium loading was as low as 0.2 mol %, which is important for industrial application and is a step forward in solving catalyst activation/deactivation problems.

C - S coupling using a mixed-ligand Pd catalyst: A highly effective strategy for synthesizing arylthio-substituted heterocycles

C - S coupling: A variety of arylthio-substituted heterocycles can be prepared through C - S coupling of the corresponding halide-substituted heterocycles by using a mixed-ligand palladium catalyst, [Pd2(dba) 3]/ Xantphos/CyPF-tBu (see scheme; dba=dibenzylideneacetone). This catalytic system is extremely powerful and efficient, allowing even C - Cl bond activation.

Copper oxide nanoparticle-catalyzed chalcogenation of the carbon-hydrogen bond in thiazoles: Synthesis of 2-(organochalcogen) thiazoles

We present (homepage: www.ufsm.br) herein the application of copper nanoparticles/dio-rganyl dichalcogenides to promote the synthesis of 2-(organochalcogen)thiazoles via direct carbon-hydro-gen bond activation in thiazoles. A systematic study of the catalytic system revealed that the presence and amount of base played an essential role in this reaction. The results revealed that electron-donating and electron-withdrawing substituents, in the aromat-ic ring bonded to the chalcogen atom of diorganyl di-chalcogenides, required one equiv. of base, while when neutral substituents were present two equiv. of base were needed to deliver the products in similar yields.

Regioselective functionalization of the thiazole scaffold using TMPMgCl?LiCl and TMP2Zn?2MgCl2?2LiCl

A general method for the synthesis of 2,4,5-trisubstituted thiazoles has been developed. Starting from commercially available 2-bromothiazole, successive metalations using TMPMgCl?LiCl or TMP2Zn?2MgCl 2?2LiCl lead to the correspondin

One-pot synthesis of symmetrical and unsymmetrical aryl sulfides by Pd-catalyzed couplings of aryl halides and thioacetates

Aryl sulfides were obtained from the coupling reaction of S-aryl (or S-alkyl) thioacetates and aryl bromides in the presence of palladium catalyst. This reaction method enables the one-pot synthesis of symmetrical and unsymmetrical diaryl sulfides by employing potassium thioacetate with aryl iodides and aryl bromides.

Oxidative amination of heteroaromatic zinc reagents mediated by PhI(OAc)2

The oxidative amination of functionalized heterocycles has been achieved by using readily available heterocyclic zinc reagents and lithium amides. PhI(OAc)2 proved to be a suitable reagent for this oxidative amination