33347-88-5

Basic information

• Product Name: 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-methoxyphenyl)-2-methyl-
• CAS NO: 33347-88-5
• Molecular Formula: C12H14N2O2
• Molecular Weight: 218.255
• Mol File: 33347-88-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-methoxyphenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-methoxyphenyl)-2-methyl-(33347-88-5)
• EPA Substance Registry System: 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-methoxyphenyl)-2-methyl-(33347-88-5)

Safety Data

• Hazardous Substances Data: 33347-88-5(Hazardous Substances Data)

Upstream product

• 3153-44-4 4-(4-methoxy-phenyl)-4-oxo-butyric acid 
• 1017-06-7 6-(4-Methoxyphenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 74-88-4 methyl iodide 
• 60-34-4 methylhydrazine 
• 15118-67-9 ethyl 3-(4-methoxybenzoyl)-propionate 

Downstream Products

• 2472-78-8 6-(4-methoxyphenyl)-2-methyl-2H-pyridazin-3-one 
• 1333420-51-1 C₁₅H₁₈N₂O₃ 
• 1333420-46-4 C₁₅H₁₈N₂O₃ 
• 1005401-46-6 2-methyl-6-{4-[3-((R)-2-methylpyrrolidin-1-yl)propoxy]phenyl}-2H-pyridazin-3-one hydrochloride 
• 1005402-21-0 6-[4-(3-chloropropoxy)phenyl]-2-methyl-2H-pyridazin-3-one 
• 1005402-20-9 6-(4-hydroxyphenyl)-2-methyl-2H-pyridazin-3-one 

Relevant articles and documents

4-Phenoxypiperidine pyridazin-3-one histamine H3 receptor inverse agonists demonstrating potent and robust wake promoting activity

Structure-activity relationships for a series of phenoxypiperidine pyridazin-3-one H3R antagonists/ inverse agonists are disclosed. The search for compounds with improved hERG and DAT selectivity without the formation of in vivo active metaboli

Amine-constrained pyridazinone histamine H3 receptor antagonists

Pyridazinone 1 was recently reported as a potent H3R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these efforts, a new class of (S)-2-pyrrolidin-1-ylmethyl-1-pyrrolidinyl amides was identified.

Pyridizinone derivatives

The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.