3335-86-2

Downstream Products

• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 723740-23-6 3-acetoxy-1-methyl-indolin-2-one 
• 622404-81-3 1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl benzoate 
• 603-76-9 1-methylindole 
• 61-70-1 N-methyl-2-indolinone 
• 1360769-04-5 (S)-3-hydroxy-3-((S)-3-hydroxy-1-phenylpropyl)indolin-2-one 
• 1360769-02-3 (R)-3-hydroxy-3-((S)-3-hydroxy-1-phenylpropyl)indolin-2-one 
• 1360769-06-7 C₂₂H₂₃NO₄ 
• 1360769-20-5 C₂₂H₂₅NO₄ 
• 1366043-15-3 (R)-3-hydroxy-1-methyl-3-((S)-2-nitro-1-phenylethyl)indolin-2-one 
• 1366043-31-3 C₁₇H₁₈N₂O₂ 

Relevant academic research and scientific papers

3-Hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-one as a versatile intermediate for retro-Henry and Friedel-Crafts alkylation reactions in aqueous medium

The first example of a retro-Henry type reaction is reported using 3-hydroxy-3-((3-methyl-4-nitroisoxazol-5-yl)methyl)indolin-2-ones which are prepared via catalyst-free Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin. These compounds were used

Ferric(III) chloride catalyzed intramolecular cyclization of N-alkyl-2-oxo-acetanilides: A facile access to isatins

A facile strategy for the synthesis of isatins in high yield from N-alkyl-2-oxo-acetanilides has been developed via Friedel-Crafts alkylation using FeCl3 as catalyst under air. This reaction proceeds through direct intramolecular addition and oxidation in one pot. Also this methodology is operationally simple, atom economical, and environment friendly.

Reductive coupling of isatins with ketones and aldehydes by low-valent titanium

The reductive coupling of isatins with ketones and aldehydes by Zn-TiCl4 in THF gave two- and four-electron reduced products, 3-hydoxy-3-(1-hydoxyalkyl)oxindoles and 3-alkylideneoxindoles, selectively by controlling the reaction conditions. Alt

Copper-catalyzed intramolecular C-H oxidation/acylation of formyl- N -arylformamides leading to indoline-2,3-diones

A new, efficient Cu-catalyzed intramolecular C-H oxidation/acylation method has been developed for the synthesis of substituted indoline-2,3-diones (isatins). In the presence of CuCl2 and O2, a variety of formyl-N-arylformamides underwent the tandem reaction to afford the corresponding indoline-2,3-diones in moderate to good yields. It is noteworthy that the reaction serves as the first example of transition-metal-catalyzed transformation for the preparation of indoline-2,3-diones.