3336-49-0 Usage
Uses
Used in Pharmaceutical Industry:
Isoquinolin-4-ol is used as a synthetic intermediate for the production of cis-Hydroxy Solifenacin and cis-Hydroxy Solifenacin N-Oxide. These metabolites are derived from Solifenacin, a muscarinic M3 receptor antagonist, which is utilized in the treatment of urinary incontinence.
Additionally, due to its high anti-radical, hypnotic-sedative, and myorelaxant activities, Isoquinolin-4-ol can be further explored for potential applications in the development of medications targeting various health conditions, such as insomnia, muscle relaxation, and oxidative stress-related disorders.
Synthesis Reference(s)
Journal of the American Chemical Society, 69, p. 1946, 1947 DOI: 10.1021/ja01200a032
Check Digit Verification of cas no
The CAS Registry Mumber 3336-49-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,3 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 3336-49:
(6*3)+(5*3)+(4*3)+(3*6)+(2*4)+(1*9)=80
80 % 10 = 0
So 3336-49-0 is a valid CAS Registry Number.
InChI:1S/C9H7NO/c11-9-6-10-5-7-3-1-2-4-8(7)9/h1-6,11H
3336-49-0Relevant academic research and scientific papers
Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions
Xia, Shanghua,Gan, Lu,Wang, Kailiang,Li, Zheng,Ma, Dawei
supporting information, p. 13493 - 13496 (2016/10/31)
The combination of Cu(acac)2 and N,N′-bis(4-hydroxyl-2,6-dimethylphenyl)oxalamide (BHMPO) provides a powerful catalytic system for hydroxylation of (hetero)aryl halides. A wide range of (hetero)aryl chlorides bearing either electron-donating or -withdrawing groups proceeded well at 130 °C, delivering the corresponding phenols and hydroxylated heteroarenes in good to excellent yields. When more reactive (hetero)aryl bromides and iodides were employed, the hydroxylation reactions completed at relatively low temperatures (80 and 60 °C, respectively) at low catalytic loadings (0.5 mol % Cu).
