3337-86-8Relevant articles and documents
EXTRUSION REACTIONS-VI. TRANSFORMATIONS OF BETA(4-QUINAZOLINYLTHIO)KETONES TO 3-(BETA KETOALKYL)-4(3H)-QUINAZOLONE DERIVATIVES
Singh, Harjit,Deep, Kanwal
, p. 4937 - 4940 (2007/10/02)
4-(4-Quinazolinylthio)-butan-2-one and 3-(4-quinazolinylthio) propiophenone (4, R=CH3, C6H5) with POCl3 give 3-(3-oxobutyl)-4(3H)-quinazolone and 3-(2-benzoylethyl)-4(3H)-quinazolone (7, R=CH3, C6H5, X=O) via S N rearrangement followed by =C=S to =C=O conversion.Non-protic heterocyclic thioamides undergo similar oxidation.
Reaction of 2-Aminobenzamide Analogs and 2-Aminothiophenol with Ethyl 3-Ethoxymethylene-2,4-dioxovalerate. Synthesis of Pyrroloquinazoline and Pyrrolobenzothiazoline Derivatives
Kurihara, Takushi,Tani, Tsutomu,Maeyama, Sigeru,Sakamoto, Yasuhiko
, p. 945 - 951 (2007/10/02)
The reaction of ethyl 3-ethoxymethylene-2,4-dioxovalerate (EMDV) (1) with 2-aminobenzamide (2), 2-aminobenzthioamide (3), 2-aminobenzmethylamide (4) and 3-amino-2-methyl- or phenylpyrazole-4-carboxamides (6 and 7) produced ethyl 3-aminomethylene-2,4-dioxovalerates (10, 15, 16, 18 and 19), which led to pyrroloquinazoline-1,5-diones (11, 22 and 23) and pyrrolopyrazolopyrimidine-1,5-diones (24 and 25) under the acidic condition, respectively.Analogously, 2-aminothiophenol reacted with 1 to give 21, which was subsequently derived to pyrrolobenzothiazolin-1-one (26) under the neutral condition.Furthermore, we prepared the heterocyclic steroidal molecules (41, 43, 45, 47, 49 and 51) by condensation of 11 and 26 with hydrazine, methylhydrazine and phenylhydrazine.