333743-68-3

Upstream product

• 259103-43-0 7-chloro-5-[(2,3-difluorobenzyl)sulfanyl][1,3]thiazolo[4,5-d]pyrimidin-2-amine 

Downstream Products

• 333743-69-4 7-chloro-5-[(2,3-difluorophenylmethyl)thio]-2-methoxythiazolo[4,5-d]pyrimidine 
• 333743-70-7 7-chloro-5-[[(2,3-difluorophenyl)methyl]thio][1,3]thiazolo[4,5-d]-pyrimidin-2(3H)-one 

Relevant academic research and scientific papers

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction

As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.

Thiazolo (4,5-D) pyrimidine compounds

The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therap