333743-72-9

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 333743-71-8 (2R)-2-[(2-Amino-5-mercaptothiazolo[4,5-d]pyrimidin-7-yl)amino]-1-propanol 
• 354565-90-5 (2R)-2-[[2-Amino-5-[(phenylmethyl)sulphonyl]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol 
• 72364-46-6 (2-fluorophenyl)methanethiol 
• 333742-99-7 (R)-2-[[2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-1-propanol 
• 259103-40-7 6-amino-1,4-dihydro-4-oxo-2-[(phenylmethyl)thio]-5-pyrimidinyl ester thiocyanic acid 
• 259100-47-5 2-Amino-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-7(4H)-one 
• 259103-38-3 7-chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-amine 

Downstream Products

• 333743-74-1 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol 
• 333743-73-0 2-[[2-bromo-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol 

Relevant academic research and scientific papers

SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction

As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.

Thiazolo (4,5-D) pyrimidine compounds

The invention provides certain thiazolopyrimidine compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therap