333754-84-0

Upstream product

• 1135-15-5 dihydroisoferulic acid 
• 603-35-0 triphenylphosphine 
• 736109-58-3 1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one 
• 110037-35-9 3-hydroxyl-4-methoxycinnamic aldehyde 

Downstream Products

• 245650-17-3 (3S)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid 

Relevant academic research and scientific papers

Preparation method of 3-hydroxy-4-methoxyphenylpropylaldehyde

The invention provides a preparation method of 3-hydroxy-4-methoxyphenylpropylaldehyde. The preparation method comprises the following steps: 1, ring opening: subjecting sassafras oil, methanol and an alkaline reagent to a reaction to obtain a phenol potassium salt solution; 2, etherification: subjecting the phenol potassium salt solution to reacting with an excessive methylation reagent to obtain mixed ether; 3, hydrolysis: subjecting the mixed ether to reacting with alcohol, water and a catalyst to obtain a hydrolyzed oil phase; 4, esterification: subjecting the hydrolyzed oil phase to reacting with acetic anhydride to obtain an acetyl intermediate product; 5, ozonization and reduction: subjecting the acetyl product to reacting with ozone, and adding a pyrosulfite solution for reduction to obtain a reduced oil phase; 6, alcoholysis: performing alcoholysis on the oil phase obtained in the step 5 to obtain a crude isovanillin product; 7, condensation; and 8, hydrogenation. The preparation method solves the problems that isovanillin is few in source and high in price, and production of a 3-hydroxy-4-methoxyphenylpropyl aldehyde intermediate is limited in the prior art, and has the advantages of being high in yield and low in cost.

Crystals of aspartame derivative

N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercia

Process for producing cinnamaldehyde derivatives, use thereof and the like

A process for conveniently and efficiently producing a highly pure cinnamaldehyde derivative, for example, (2E)-(3-hydroxy-4-methoxy)cinnamaldehyde, which comprises reacting a benzaldehyde derivative, such as isovanillin and the like, with acetaldehyde in

Process for production of aspartyl dipeptide ester derivative, novel production intermediate therefor, and process for production thereof

The present invention relates to a method of manufacturing aspartyl dipeptide ester compounds, which can be used as sweeteners, and aldehydes that can be used in the manufacturing processes.