33383-52-7

Upstream product

• 122-00-9 para-methylacetophenone 
• 17263-64-8 2-diazo-1-(4-methylphenyl)ethanone 
• 619-41-0 4-(bromoacetyl)toluene 

Relevant academic research and scientific papers

Cyclotrimerization for the Synthesis of Cyclopropanes

The synthesis of small rings by functionalization of C(sp3)-H bonds remains a great challenge. We report for the first time a copper-catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives under mild reaction conditions. The reaction has a broad scope for the stereoselective synthesis of cyclopropanes by trimerization of acetophenone. The developed transformation is based on an extraordinary copper-catalyzed cascade process that allows saturated carbocycles to be obtained for the first time by cyclotrimerization through functionalization of C(sp3)-H bonds. The cascade of sixfold C(sp3)-H bond functionalization allows the synthesis of cyclopropanes in a highly stereoselective approach. Give it a tri: Copper-catalyzed oxidative [1+1+1] cyclotrimerization of acetophenone derivatives under mild reaction conditions and with a broad reaction scope has been developed. This transformation is a radical cascade process that allows saturated carbocycles to be obtained by cyclotrimerization through functionalization of C(sp3)-H bonds.

trans-1,2,3-Tris(aroyl)- and trans-1,2,3-Tris(heteroaroyl)-cyclopropanes via Cyclotrimerization of α-Bromo ketones in the System K2CO3/DMF.

Treatment of α-bromoketones (1) with K2CO3 in DMF resulted in a deviation from the expected Darzens-type condensation affording exclusively trans-1,2,3-trisubstituted cyclopropanes (3).

Generation of the Selenonium Ylide by the Carbenic Reaction. Formation of Cyclopropane Derivatives via Selenonium Ylide

The Cu(acac)2-catalyzed decomposition of α-diazoacetophenones in the presence of bis(p-methoxy-phenyl) selenide (3) did not give the corresponding selenonium ylide but gave r-l,c-2,t-3-tribenzoylcylopropanes through the successive reaction of the intermed