333999-62-5

Basic information

• Product Name: (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol
• Synonyms: (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol
• CAS NO: 333999-62-5
• Molecular Weight: 480.604
• Mol File: 333999-62-5.mol

Chemical Properties

• CAS DataBase Reference: (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol(333999-62-5)
• EPA Substance Registry System: (1S,3S,6S,7S,8S,9S)-3-(N-benzyloxycarbonyl-N-methylamino)-6-(4-methoxybenzyl)-5-azatricyclo[6.3.1.0^1,5]dodecane-7,9-diol(333999-62-5)

Safety Data

• Hazardous Substances Data: 333999-62-5(Hazardous Substances Data)

Upstream product

• 1449125-52-3 (2Z,5S,6S,7S,10aS)-6,8-bis{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxyimino)-5-(4-methoxybenzyl)-octahydro-3H-7,10a-methanopyrrolo[1,2-a]azocin-3-one 
• 1449125-48-7 (5S,6S,7S,10aR)-6,8-bis{[tert-butyl(dimethyl)silyl]oxy}-5-(4-methoxybenzyl)octahydro-3H-7,10amethanopyrrolo[1,2-a]azocin-3-one 
• 1449125-47-6 (5S,6S,7R,10aR)-8-{[tert-butyl(dimethyl)silyl]oxy}-6-hydroxy-5-(4-methoxybenzyl)octahydro-3H-7,10a-methanopyrrolo[1,2-a]azocin-3-one 
• 1240017-54-2 (5S,7S,10aR)-8-{[tert-butyl(dimethyl)silyl]oxy}-5-(4-methoxybenzyl)tetrahydro-1H-7,10a-methanopyrrolo[1,2-a]azocine-3,6(2H,5H)-dione 
• 1240017-60-0 (5S,6R,7R,10aR)-8-{[tert-butyl(dimethyl)silyl]oxy}-6-hydroxy-5-(4-methoxybenzyl)octahydro-3H-7,10a-methanopyrrolo[1,2-a]azocin-3-one 
• 1240017-59-7 (5S,6R,7S,10aR)-6,8-dihydroxy-5-(4-methoxybenzyl)octahydro-3H-7,10a-methanopyrrolo[1,2-a]-azocin-3-one 
• 1240017-65-5 (5S,6R,7R,10aR)-6-hydroxy-5-(4-methoxybenzyl)tetrahydro-1H-7,10a-methanopyrrolo[1,2-a]azocine-3,8(2H,5H)-dione 
• 1240017-64-4 (2S)-2-(2,8-dioxo-1-azaspiro[4.5]dec-1-yl)-3-(4-methoxyphenyl)propanal 
• 1240017-58-6 1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,8-dione 
• 1240017-57-5 8,8-dimethoxy-1-[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]-1-azaspiro[4.5]decane-2,4-dione 
• 1240017-55-3 methyl 1-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-4,4-dimethoxycyclohexanecarboxylate 
• 1240017-56-4 8-{acetyl[(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]amino}-N-(4-methoxyphenyl)-1,4-dioxaspiro[4.5]decane-8-carboxamide 
• 1163716-52-6 (2S)-1-(4-methoxyphenyl)but-3-en-2-amine 
• 1240017-63-3 tert-butyl [(2S)-1-(4-methoxyphenyl)but-3-en-2-yl]carbamate 

Downstream Products

• 248948-75-6 (2S,5S,6S,7R,8S,10aS)-2-[[(benzyloxy)carbonyl]methylamino]octahydro-6-hydroxy-5-[(4-methoxyphenyl)methyl]-1H-7,10a-methanopyrrolo[1,2-a]azocin-8-yl dibenzyl phosphate 

Relevant articles and documents

Total synthesis of (-)-FR901483

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Stereocontrolled total synthesis of (-)-FR901483

The total synthesis of a potent immunosuppressant (-)-FR901483 is accomplished. The skeleton itself is constructed by the Ugi 4CC reaction, subsequent intramolecular Dieckmann condensation, and a diastereoselective intramolecular aldol reaction. However, the remarkable feature is the stereoselective incorporation of the p-methoxybenzyl and methylamino groups within the tricyclic core skeleton.

Total synthesis of tricyclic azaspirane derivatives of tyrosine: FR901483 and TAN1251C

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