334002-70-9

Upstream product

• 7304-32-7 2-fluoro-5-nitrobenzoic acid 
• 334002-51-6 methyl 2,3-deoxy-3-(azido)-4,6-O-isopropylidene-β-D-glucosamine 
• 334002-67-4 methyl 2-deoxy-4,6-O-isopropylidene-N-(trifluoroacetamido)-β-D-allosamine 
• 660438-72-2 methyl 2-deoxy-3-O-(methanesulfonyl)-4,6-O-isopropylidene-N-(trifluoroacetamido)-β-D-allosamine 
• 334002-69-6 methyl 2,3-deoxy-3-(azido)-4,6-O-isopropylidene-N-(trifluoroacetamido)-β-D-glucosamine 
• 334002-66-3 methyl 2-deoxy-4,6-O-isopropylidene-N-(trifluoroacetamido)-β-D-ribo-hex-3-ulopyranoside 
• 40299-08-9 methyl 2-deoxy-2-trifluoroacetamido-β-D-glucopyranoside 

Downstream Products

• 660438-35-7 (4aR,6R,6aR,13aR,13bS)-7,13-Dibenzyl-6-methoxy-2,2-dimethyl-10-nitro-4a,6a,7,13,13a,13b-hexahydro-4H,6H-1,3,5-trioxa-7,13-diaza-benzo[5,6]cyclohepta[1,2-a]naphthalen-8-one 
• 334002-71-0 methyl 2,3-deoxy-3-(amino)-4,6-O-isopropylidene-N-(2-fluoro-5-nitro-benzamido)-β-D-glucopyranoside 

Relevant academic research and scientific papers

Novel Chimeric Scaffolds to Extend the Exploration of Receptor Space: Hybrid β-D-Glucose-Benzoheterodiazepine Structures for Broad Screening. Effect of Amide Alkylation on the Course of Cyclization Reactions

New molecular platforms which are hybrids of two scaffolds-namely, β-D-glucose and benzodiazepine, each able to bind several proteins-were designed, synthesized and functionalized to serve as probes for broad biological screening. Herein, we describe the syntheses and chemical properties of these novel chimeric scaffolds. Attempted cyclization of the functionalized analogues (-)-96 and (-)-97 afforded the corresponding dimers (-)-98 and (-)-99, respectively, under a variety of reaction conditions, even at concentrations of only 0.001 N. Consideration of factors affecting the conformation of amide bonds and their effects on cyclization reactions led us to alkylate the amide bond. As expected, the cyclization of the N-methyl derivative (-)-110 afforded exclusively the unimolecular cyclization product (+)-111. These compounds are only now undergoing broad screening and represent therefore at present a "prospecting library".

Design and synthesis of novel scaffolds for drug discovery: hybrids of beta-D-glucose with 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one, the corresponding 1-oxazepine, and 2- and 4-pyridyldiazepines.

[structure: see text]. We describe the syntheses of novel tricyclic scaffolds that incorporate a fusion of a substituted pyranose ring with the seven-membered rings of 1,2,3,4-tetrahydrobenzo[e][1,4]diazepin-5-one and the corresponding oxazepine and pyrid