334022-50-3

Upstream product

• 334022-44-5 tert-Butyl-[4-methoxy-3-((2R,4aR,8R,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-benzyloxy]-dimethyl-silane 
• 334022-49-0 [4-Methoxy-3-((2R,4aR,8R,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-phenyl]-phenyl-methanol 
• 334022-47-8 [4-Methoxy-3-((2R,4aR,8R,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-phenyl]-methanol 
• 334022-48-9 4-Methoxy-3-((2R,4aR,8R,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-benzaldehyde 
• 135214-83-4 1,5-Anhydro-2-deoxy-4,6-O-(phenylmethylene)-D-arabino-hexopyranoside 
• 334022-45-6 [4-Methoxy-3-((2R,4aR,8R,8aS)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy)-phenyl]-phenyl-methanone 

Downstream Products

• 334022-46-7 Toluene-4-sulfonic acid (2R,3S,4R)-4-(5-benzoyl-2-methoxy-phenoxy)-3-hydroxy-tetrahydro-pyran-2-ylmethyl ester 
• 334022-51-4 {3-[(2S,3S,4R)-2-(Diphenyl-phosphinoylmethyl)-3-hydroxy-tetrahydro-pyran-4-yloxy]-4-methoxy-phenyl}-phenyl-methanone 

Relevant academic research and scientific papers

Catalytic enantioselective cyanosilylation of ketones: Improvement of enantioselectivity and catalyst turn-over by ligand tuning

Sterical and electronical tuning of the bifunctional catalyst 1 afforded the improved catalyst 2, which promoted the cyanosilylation of ketones with higher enantioselectivity as well as with improved catalyst turn-over with a factor of up to 10. Thus, chiral quaternary α-hydroxynitriles were obtained with excellent ee (up to 94% ee) using 1 mol% of 2 in the case of aryl ketones and 2.5 mol% of 2 in the case of aliphatic ketones.