334023-32-4Relevant academic research and scientific papers
Facile and stereoselective synthesis of non-racemic 3,3,3-trifluoroalanine
Crucianelli, Marcello,Battista, Natalia,Bravo, Pierfrancesco,Volonterio, Alessandro,Zanda, Matteo
, p. 1251 - 1258 (2007/10/03)
A highly stereoselective enantiodivergent synthesis of non-racemic 3,3,3-trifluoroalanine 7 is reported. The methodology is based on the reduction, by 9-BBN or DIBAH, of the chiral sulfinimine 3 derived from ethyl trifluoropyruvate, followed by acidic hydrolysis of the resulting diastereomeric sulfinamides 4 and 5.
