3341-41-1

Usage

Uses

Used in Organic Synthesis:
1-[1-(phenylamino)cyclopentyl]ethanone is used as a building block for the synthesis of more complex organic molecules. Its unique structure allows for the formation of various chemical bonds and reactions, making it a valuable component in the creation of new compounds with specific properties.
Used in Pharmaceutical Research:
1-[1-(phenylamino)cyclopentyl]ethanone is used as a starting material or intermediate in the development of new pharmaceutical agents. Its structural features and reactivity may contribute to the discovery of novel drugs with therapeutic potential in various medical fields.
Used in Chemical Research:
1-[1-(phenylamino)cyclopentyl]ethanone is used as a research tool in the study of chemical reactions and mechanisms. Its unique structure and reactivity can provide insights into the behavior of similar compounds and help advance the understanding of chemical processes.

Upstream product

• 765-87-7 cyclohexane-1,2-dione 
• 96304-02-8 2-hydroxy-2-methylcyclohexanone 
• 62-53-3 aniline 
• 1422514-64-4 6-methyl-1,4-dioxaspiro[4.5]decan-6-ol 
• 4746-96-7 1,4-dioxaspiro[4.5]decan-6-one 

Relevant academic research and scientific papers

Improved methods for thermal rearrangement of alicyclic α-hydroxyimines to α-aminoketones: Synthesis of ketamine analogues as antisepsis candidates

Ketamine is an analgesic/anesthetic drug, which, in combination with other drugs, has been used as anesthetic for over 40 years. Ketamine induces its analgesic activities by blocking the N-methyl-D-aspartate (NMDA) receptor in the central nervous system (CNS). We have reported that low doses of ketamine administrated to patients before incision significantly reduced post-operative inflammation as reflected by reduced interleukin-6 (IL-6) sera-levels. Our data demonstrated in a rat model of Gram-negative bacterial-sepsis that if we inject a low dose of ketamine following bacterial inoculation we reduce mortality from approximately 75% to 25%. Similar to what we have observed in operated patients, the levels of TNF-α and IL-6 in ketamine-treated rats were significantly lower than in septic animals not treated with ketamine. On the base of these results, we have designed and synthesized series of new analogues of ketamine applying a thermal rearrangement of alicyclic α-hydroxyimines to α-aminoketones in parallel arrays. One of the analogues (compound 6e) displayed high activity in down-regulating the levels of IL-6 and TNF-α in vivo as compared to ketamine.