33413-75-1

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 43114-66-5 10-Ethoxymethyl-9-(3-nitrophenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,-9,10-decahydroacridine 

Relevant academic research and scientific papers

Synthesis of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2Н,5Н)-diones

The reaction in a mixture of 1,3-cyclohexanedione (dimedone), arylaldehyde, and ammonium acetate at 160°C during 10–15 min in the absence of solvent leads to the formation of 9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-diones. The structure of the pr

Efficient iron catalyzed ligand-free access to acridines and acridinium ions

Acridines and acridinium ions are one of the important classes of compounds in terms of their usefulness in pharmaceuticals, materials, dyes and photo-catalysis. Here we present an unconventional FeCl3-alcohol catalysed one-pot method for their

Hollow Fe3O4@DA-SO3H: an efficient and reusable heterogeneous nano-magnetic acid catalyst for synthesis of dihydropyridine and dioxodecahydroacridine derivatives

Abstract: In this work, for the first time, a highly stable and efficient super-paramagnetic catalyst, H-Fe3O4@DA-SO3H, involving hollow morphology of Fe3O4 as core and dopamine as shell was prepared

Fe3O4@SiO2-MoO3H nanoparticles: A magnetically recyclable nanocatalyst system for the synthesis of 1,8-dioxo-decahydroacridine derivatives

Molybdic acid-functionalized silica-coated nano-Fe3O4 particles (Fe3O4@SiO2-MoO3H) have been prepared as a novel heterogeneous acid catalyst using a facile process. The material was subsequ

Nano-zirconia as an excellent nano support for immobilization of sulfonic acid: A new, efficient and highly recyclable heterogeneous solid acid nanocatalyst for multicomponent reactions

Nano-zirconia-supported sulfonic acid [nano-ZrO2-SO3H (n-ZrSA)] is synthesized by immobilizing sulfonic acid groups on the surface of nano zirconium dioxide to produce a novel heterogeneous reusable solid acid nanocatalyst. This new nanocatalyst is characterized by FT-IR spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), the Hammett acidity function and pH analysis. The introduced nano-zirconia-supported sulfonic acid is used as an efficient and recyclable catalyst for different heterocyclic multicomponent reactions such as the synthesis of hexahydroquinoline, 1,8-dioxo-decahydroacridine, polyhydroquinoline and 1,8-dioxo-octahydroxanthene derivatives. Optimization of the reaction conditions was studied using a central composite design (CCD) which is one of the most widely used response surface methodologies. The newly prepared heterogeneous solid acid nanocatalyst is easily separated and reusable for five cycles without any apparent loss of its catalytic activity, which confirmed the stability of the covalent bonding of the sulfonic acid groups. n-ZrSA has advantages such as its low cost, low toxicity, ease of preparation, good stability, high reusability and operational simplicity.

A new MCM-41 supported HPF6 catalyst for the library synthesis of highly substituted 1,4-dihydropyridines and oxidation to pyridines: Report of one-dimensional packing towards LMSOMs and studies on their photophysical properties

A new heterogeneous MCM-41 silica supported HPF6 catalyst has been synthesized and characterized using an array of sophisticated analytical techniques like BET, XRD, HRTEM, EDX, 29Si MAS NMR, TGA, FTIR, and pH measurement. The broad

An efficient one-pot synthesis of 1,8-dioxo-decahydroacridines by Ionic liquid with multi-SO3H groups under ambient temperature in water

Ionic liquid with multi-SO3H groups was employed as a catalyst for facile preparation of 1,8-dioxo-decahydroacridines via the one-pot condensation of various aldehydes, 1,3-diketones with aromatic amines or ammonium acetate. Various aromatic aldehydes were utilized in the reaction and in all situations the desired product were synthesized successfully. The described novel synthesis method propose several advantages of safety, mild condition, short reaction times, high yields, simplicity and easy workup compared to the traditional method of synthesis.

Polyethylene glycol-mediated synthesis of decahydroacridine-1,8-diones catalyzed by ceric ammonium nitrate

Polyethylene glycol was found to be an inexpensive non-toxic and effective medium for one pot synthesis of high yields of decahydroacridine-1,8-diones in the presence of ceric ammonium nitrate as the catalyst. Moreover, the solvent can be recovered and re

Environmentally friendly and efficient synthesis of various 1,4-dihydropyridines in pure water

An environmentally friendly and efficient synthesis of a series of 1,4-dihydropyridines was developed by the practical one-pot reactions of aldehydes with ammonium acetate and 1,3-dicarbonyl compounds such as alkyl acetoacetate, 5,5-dimethyl-1,3-cyclohexanedione, 1,3-cyclohexanedione, and 2,4-pentanedione in water without any additives under refluxing conditions.

Synthesis and pharamacological screening of 1,8-dioxo-9-(substituted phenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridines

1,8-Dioxo-9--1,2,3,4,5,6,7,8,9,10-decahydroacridines (B4-B5) and 1,8-dioxo-9-(substituted phenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridines (B6-B31) have been prepared by the condensation of substituted glucosyloxy benzaldehydes (A1-A5) and substituted benzaldehydes (A6-A31) in the presence of ammonium hydroxide using ethanol as a solvent, and their structures established by IR, PMR and mass spectral data.The compounds B1-B31 have been tested for cardiovascular, antiinflammatory, antibacterial andantiimplantation activities.