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2'-Deoxy-5-fluorouridine 3',5'-dibutanoate is a chemical compound with the molecular formula C16H23FN2O6. It is a derivative of 2'-deoxyuridine, a naturally occurring nucleoside, where the 5-hydroxyl group is replaced with a fluorine atom, and the 3' and 5' hydroxyl groups are esterified with butanoic acid. This modification enhances the compound's stability and bioavailability. It is used in medicinal chemistry, particularly in the development of antiviral and anticancer drugs, due to its ability to interfere with DNA synthesis and repair mechanisms in target cells. The compound's unique structure allows it to be incorporated into DNA, leading to the inhibition of DNA polymerase and ultimately cell death. Its potential applications in therapeutics are under investigation, and it serves as an important tool in understanding the mechanisms of nucleoside analogs in cancer treatment and antiviral therapy.

3343-22-4

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3343-22-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3343-22-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,4 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 3343-22:
(6*3)+(5*3)+(4*4)+(3*3)+(2*2)+(1*2)=64
64 % 10 = 4
So 3343-22-4 is a valid CAS Registry Number.

3343-22-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3',5'-di-O-butanoyl-5-fluoro-2'-deoxyuridine

1.2 Other means of identification

Product number -
Other names 3',5'-O-dibutyryl-floxuridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3343-22-4 SDS

3343-22-4Relevant academic research and scientific papers

Regioselective acylation of nucleosides and their analogs catalyzed by Pseudomonas cepacia lipase: enzyme substrate recognition

Li, Ning,Zong, Min-Hua,Ma, Ding

supporting information; experimental part, p. 1063 - 1068 (2009/04/11)

The substrate recognition of Pseudomonas cepacia lipase in the acylation of nucleosides was investigated by means of rational substrate engineering for the first time. P. cepacia lipase displayed excellent 3′-regioselectivities (96 to >99%) in the lauroyl

Regioselective acylation of nucleosides catalyzed by candida antarctica lipase B: Enzyme substrate recognition

Li, Ning,Zong, Min-Hua,Ma, Ding

supporting information; scheme or table, p. 5375 - 5378 (2009/05/07)

The substrate recognition of Candida antarctica lipase B (CAL-B) in the acylation of nucleosides was revealed through rational substrate engineering for the first time. CAL-B displayed lower activities and excellent 5′-regioselectivities (94 to >99%) in t

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