33442-36-3

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 106-49-0 p-toluidine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 98-56-6 4-chlorobenzotrifluoride 

Downstream Products

• 178946-89-9 bis(3-indolyl)-4-chlorophenylmethane 
• 109858-88-0 2-(4-Chloro-phenyl)-1-phenethyl-3-p-tolyl-2,3-dihydro-1H-quinazolin-4-one 
• 96541-52-5 2-(4-methylanilino)-2-(4-chlorophenyl)acetonitrile 
• 33863-79-5 N-(4-chlorobenzyl)-4-methylbenzeneamine 

Relevant academic research and scientific papers

Substituent effects on the mesogenic benzylidenes of 4-methylaniline: Synthesis, characterization, DFT, NLO, photophysical, molecular docking, and antibacterial studies

Substituted benzylidene anilines forming donor-π-acceptor (D-π-A) molecular systems are the models of molecular mesogenic cores for NLO applications. The effect of the benzylidene substituents on the sensitivity of the electronic properties of the azometh

Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases

We communicate two mild, solvent-free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C?F bond activation, accompanied with utilisation of Si-based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. (Figure presented.).

Systematic studies on mechanochemical synthesis: Schiff bases from solid aromatic primary amines and aldehydes

A versatile and robust mechanochemical route to Aldehyde–Schiff base conversions has been established for a broad range of aldehydes via a simple cogrinding in mortar with a pestle under a solvent-free, as well as solvent-assisted, environment. The extent

Application of a catalyst-free Domino Mannich/Friedel-Crafts alkylation reaction for the synthesis of novel tetrahydroquinolines of potential antitumor activity

A useful and efficient method to construct diversely substituted 1,2,3,4-tetrahydroquinolines in good to excellent yields has been developed through a catalyst-free Domino Mannich and intramolecular Friedel-Crafts alkylation reactions of N-arylamines with

Higher Order Constitutional Dynamic Networks: [2×3] and [3×3] Networks Displaying Multiple, Synergistic and Competitive Hierarchical Adaptation

The present study investigates the constitutional dynamic networks (CDNs) underlying dynamic covalent libraries (DCLs) that extend beyond the [2×2] case toward higher orders, namely [2×3] and [3×3] CDNs involving respectively six and nine constituents generated from the recombination of five and six components linked through reversible chemical reactions. It explores the behavior of such systems under the action of one or two effectors. More specifically and for the sake of proof of principle, it makes use of DCLs involving dynamic organic ligands and analyzes their single and double adaptive response under the action of one and two metal cation effectors. Thus, interconversions within [2×3] DCLs of six constituents (hydrazone, acylhydrazone, and imine ligands) give access to the generation of [2×3] CDNs of 3D trigonal prismatic type consisting of three [2×2] sub-networks and presenting specific responses to the application of Cu+ and Zn2+ metal cation effectors, in particular double agonistic amplification. More complex [3×3] CDNs based on nine ligand constituents of imine, hydrazone, and acylhydrazone types were also designed and subjected to the application of one or two effectors, e.g., Cu+ and Fe2+ metal cations, revealing novel types of adaptive behavior: (i) agonistic amplification between a single constituent and a full [2×2] sub-network, and (ii) agonistic amplification along a single diagonal connecting three constituents. Of special interest is also the dependence of the response of the system to hierarchical sequence of effector application, whereby initial interaction with Cu+ ions results in the destruction of the network, whereas the sequence Fe2+ followed by Cu+ yields a clean three-constituent DCL. Finally and strikingly, the present results also demonstrate that the increase in complexity of the system by introduction of an additional entity leads to a simpler output through dynamic competition between components.

Molecular iodine catalysed one-pot synthesis of chromeno[4,3-b]quinolin-6-ones under microwave irradiation

We demonstrate a facile one pot approach for the regioselective synthesis of chromeno[4,3-b]quinolin-6-one derivatives in excellent yields under microwave (MW) irradiation. This transformation presumably proceeds via a three-component tandem annulation of

The first aza Diels-Alder reaction involving an α,β-unsaturated hydrazone as the dienophile: Stereoselective synthesis of C-4 functionalized 1,2,3,4-tetrahydroquinolines containing a quaternary stereocenter

The reaction between aromatic imines and methacrolein dimethylhydrazone in the presence of 10% indium trichloride affords in good to excellent yields biologically and synthetically relevant 1,2,3,4-tetrahydroquinolines bearing a hydrazone function at C-4 in a one-pot process that involves the formation of two C-C bonds and the stereoselective generation of two stereocenters, one of them quaternary, and this constitutes the first example of an α,β-unsaturated dimethylhydrazone behaving as a dienophile in a hetero Diels-Alder reaction and the first vinylogous aza-Povarov reaction. This journal is The Royal Society of Chemistry.

Synthesis of highly substituted unsymmetrical 1,2-diamines, 1,2-diimines, imidazolium salts and imidazolylidenes by aldimine cross-coupling

α-Aminonitriles derived from aromatic aldehydes and primary amines can be deprotonated quantitatively without the use of protecting groups. The 1,2-addition of the resulting stabilized α-aminocarbanions to imines yields α-aminoimines and the tautomeric enediamines. These unstable compounds can directly be oxidized to 1,2-diimines or reduced to 1,2-diamines in a one-pot reaction. 1,2-Diamines can be obtained in high diastereoselectivity by reduction of the 1,2-diimines. In this case, the relative configuration of the products can be chosen depending on the reduction conditions. Cyclization of the unsymmetrical diimines with halomethyl ethers or esters leads to 1,3,4,5-tetrasubstituted imidazolium salts which can serve as starting materials for the preparation of highly substituted nucleophilic carbenes. Georg Thieme Verlag Stuttgart.

Conformational change of N-benzylideneanilines in crystals

The crystal structures of N-(4-nitrobenzylidene)aniline (1), N-(4-chlorobenzylidene)-4-methylaniline (2) and N-(4-methylbenzylidene)-4- methylaniIine (3) were determined by X-ray diffraction analyses at various temperatures. A dynamic disorder was observe