334477-30-4 Usage
Type of compound
Cyclopropane derivative
Functional group
Trifluoromethylphenyl
Application
Organic synthesis and pharmaceutical research
Use
Building block in the production of pharmaceutical drugs and agrochemicals
Trifluoromethyl group
Contributes to high lipophilicity and stability
Importance
Key component in the development of bioactive compounds and drug candidates
Check Digit Verification of cas no
The CAS Registry Mumber 334477-30-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,4,4,7 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 334477-30:
(8*3)+(7*3)+(6*4)+(5*4)+(4*7)+(3*7)+(2*3)+(1*0)=144
144 % 10 = 4
So 334477-30-4 is a valid CAS Registry Number.
334477-30-4Relevant articles and documents
Synthesis and pharmacological characterization of constrained analogues of Vestipitant as in vitro potent and orally active NK1 receptor antagonists
Sabbatini, Fabio M.,Fabio, Romano Di,Griffante, Cristiana,Pentassuglia, Giorgio,Zonzini, Laura,Melotto, Sergio,Alvaro, Giuseppe,Capelli, Anna M.,Pippo, Lara,Perdona', Elisabetta,Denis, Yves St.,Costa, Silvano,Corsi, Mauro
scheme or table, p. 623 - 627 (2010/06/12)
A focused exploration targeting conformationally restricted analogues of Vestipitant, resulted in the discovery of novel, in vitro potent NK1 antagonists. In particular, two of the compounds reported exhibited a good pharmacokinetic (PK) profile and produced anxiolytic-like effects in the gerbil foot tapping (GFT) in vivo model.