33451-35-3

Usage

Uses

Used in Pharmaceutical Industry:
(4-Chloro-butane-1-sulfonyl)-benzene is used as a building block for the synthesis of various pharmaceuticals due to its ability to participate in a range of chemical reactions, facilitating the creation of new chemical entities with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, (4-Chloro-butane-1-sulfonyl)-benzene serves as a precursor in the production of agrochemicals, contributing to the development of new compounds designed to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
(4-Chloro-butane-1-sulfonyl)-benzene is utilized as a reagent in organic synthesis, where its unique structural features allow for the formation of diverse chemical products through various transformation processes.
Used in Specialty Chemicals Production:
(4-Chloro-butane-1-sulfonyl)-benzene also acts as a precursor in the production of specialty chemicals, indicating its broad applicability across different areas of the chemical industry where specific, high-value products are required.

Upstream product

• 5851-37-6 4-(phenylthio)butan-1-ol 
• 873-55-2 sodium benzenesulfonate 
• 110-56-5 1,4-dichlorobutane 
• 108-98-5 thiophenol 
• 6940-78-9 4-chlorobutyl bromide 
• 49639-23-8 Butan-4-ol-phenylsulfoxid 
• 14633-31-9 1-chloro-4-(phenylthio)butane 

Downstream Products

• 112859-62-8 2-nitro-5-[4-(phenylsulfonyl)butoxy]benzaldehyde 
• 53893-42-8 1,4-bis(phenylsulfonyl)butane 
• 1007568-24-2 9-(4-benzenesulfonyl-butyl)-5,6,7,8-tetrahydro-9H-carbazole-3-carboxylic acid methyl ester 
• 1229622-09-6 C₂₁H₂₇NO₄S 
• 142103-94-4 5-[1-[5-(4-Benzenesulfonyl-butoxy)-2-nitro-phenyl]-meth-(Z)-ylidene]-imidazolidine-2,4-dione 
• 112859-12-8 7-[4-(phenylsulfonyl)butoxy]-1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one 
• 78710-81-3 1-iodo-4-(phenylsulfonyl)butan 

Relevant academic research and scientific papers

Synthesis of α-Cyano and α-Sulfonyl Cyclic Ethers via Intramolecular Reactions of Peroxides with Sulfone- And Nitrile-Stabilized Carbanions

The intramolecular reaction of carbon nucleophiles with oxygen-centered electrophiles has been little explored outside of nucleophilic epoxidation. We now report the synthesis of sulfonyl- and cyano-substituted oxacycles via intramolecular reaction of sul

HEPATITIS C VIRUS ENTRY INHIBITORS

The present invention relates to the use of tricyclic diphenylamine derivative compounds for prevention and/or treatment of Hepatitis C virus (HCV) infection by inhibiting HCV entry into permissive cells.

Synthesis of substituted tetrahydropyrans via intermolecular reactions of δ-halocarbanions with aldehydes

Intramolecular substitution in δ-halocarbanions leading to cyclobutanes is a relatively slow process, thus they readily add to carbonyl groups; the thus-produced anionic adducts cyclize to tetrahydropyran derivatives. A simple mechanistic discussion, opti

Synthesis and pharmacological properties of benzamide derivatives as selective serotonin 4 receptor agonists

A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamides with a polar substituent group at the 1-position of the piperidine ring was synthesized and evaluated for its effect on gastrointestinal motility. The benzoyl, phenylsulfonyl, and benzylsulfonyl derivatives accelerated gastric emptying and increased the frequency of defecation. One of them, 4-amino-N-[1-[3-(benzylsulfonyl)propyl]piperidin-4-ylmethyl]-5-chloro-2- methoxybenzamide (13a, Y-36912), was a selective 5-HT4 receptor agonist offering potential as a novel prokinetic with reduced side effects derived from 5-HT3- and dopamine D2 receptor-binding affinity. In the oral route of administration, this compound enhanced gastric emptying and defecation in mice, and has a possibility as a prokinetic agent, which is effective on both the upper and the lower gastrointestinal tract.

Design and synthesis of orally active benzamide derivatives as potent serotonin 4 receptor agonist

A series of 4-amino-5-chloro-2-methoxy-N-(piperidin-4-ylmethyl)benzamide derivatives bearing an aralkylamino, alkylamino, benzoyl or phenylsulfonyl group at its side chain part at the 1-position on the piperidine ring was synthesized. They were evaluated

The sily-durst chlorination of hydroxy sulfoxides

Treatment by sulfuryl chloride of the bis-O-TES derivative of a γ,ε-bis-hydroxy phenylsulfoxide resulted in the selective formation of the corresponding γ-chloro-ε-hydroxy phenylsulfone.

N-(arylthioalkyl)-N'-(aminoalkyl)ureas

N-(arylthioalkyl)-N'-(aminoalkyl)ureas and thioureas and oxidation derivatives having the formula STR1 wherein B is thio, sulfinyl or sulfonyl; R1 and R2 are hydrogen, loweralkyl, cycloalkyl, 2-furanyl, phenyl, substituted phenyl or phenyl-loweralkyl and R3 and R4 are hydrogen, loweralkyl, phenyl or phenyl-loweralkyl wherein phenyl is optionally substituted, or R3 and R4 taken with the adjacent nitrogen form a heterocyclic residue.