334513-03-0

Upstream product

• 334513-02-9 4-[3-(trityl-amino)-propionylamino]-butyramide 
• 450409-30-0 2,2,2-trifluoro-N-(3-{[4-(2,2,2-trifluoro-acetylamino)-butyl]-trityl-amino}-propyl)-acetamide 
• 158474-89-6 N-[4-(trifluoroacetamido)butyl]-N-[3-(trifluoroacetamido)propyl]amine 
• 58995-27-0 Trt-βAla-OSu 
• 665782-46-7 4-[3-(trityl-amino)-propionylamino]-butyric acid 
• 334513-00-7 Trt-β-Ala-γ-Aba-OSu 

Downstream Products

• 334513-15-4 3-(3,4-bis-benzyloxy-phenyl)-N-{4-[3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-butyl}-N-[3-(trityl-amino)-propyl]-acrylamide 
• 450409-20-8 1-[3-(trityl-amino)-propyl]-[1,6]diazecane-2,5-dione 

Relevant academic research and scientific papers

Synthesis and antioxidative/anti-inflammatory activity of novel fullerene-polyamine conjugates

(E)-4-(Fullerenopyrrolidin-1-yl)-3-methylbut-2-enoic acid and its corresponding succinimidyl ester, readily obtained through Prato-type modification of C60, were used for the selective N-acylation of polyamines. The thus obtained conjugates were evaluated for their antioxidative and anti-inflammatory activity and their cytotoxicity was determined. Members of this family of compounds showed interesting anti-lipid peroxidation, anti-lipoxygenase and anti-inflammatory activity and comparable cytocompatibility to spermidine.

Simple syntheses of cyclic polyamines using selectively N-tritylated polyamines and succinic anhydride

Treatment of selectively N-tritylated spermidine and spermine derivatives with succinic anhydride, followed by PyBrOP-mediated intramolecular amide bond formation and LiAlH4 reduction, allows for an easy and general entry to cyclic polyamine derivatives.

Simple syntheses of N-alkylated spermidine fragments and analogues of the spermine alkaloid kukoamine A

Acylation of a variety of amines with succinimidyl N-trityl-β-alanyl-γ-aminobutyrate and N-trityl-γ-aminobutyryl-β-alaninate, readily obtained through coupling of succinimidyl N-trityl-β-alaninate with trimethylsilyl γ-aminobutyrate and of N-trityl-γ-aminobutyric acid with methyl β-alaninate, respectively, followed by LiAlH4 reduction, produced N-monoalkylated spermidine fragments and analogues of the spermine alkaloid kukoamine A. The applicability of this methodology on the solid phase was also demonstrated.