33452-71-0Relevant academic research and scientific papers
Rapid access to α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile and the anti-proliferative activities of the products
Zhang, Xiaofei,He, Qian,Xiang, Haoyue,Song, Shanshan,Miao, Zehong,Yang, Chunhao
, p. 355 - 361 (2014)
An effective and convenient method has been developed for the preparation of 2 or 2,4-substituted α-carbolines via a one-pot tandem reaction of α,β-unsaturated ketones with 2-nitrophenylacetonitrile in the presence of zinc dust, acetic acid and triethylamine. This protocol presents a simple, rapid and pot/step economical strategy for preparing biologically interesting α-carbolines with moderate anti-tumor activities.
