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33456-68-7

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  • High quality P-[2-(3,4-Dihydro-7-Methoxy-4,4-Dimethyl-1,3-Dioxo-2(1H)Isoquinoly)Ethyl]Benzenesulphonamide supplier in China

    Cas No: 33456-68-7

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  • 4-[2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)-ethyl]-benzenesulfonamide

    Cas No: 33456-68-7

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33456-68-7 Usage

General Description

p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide is a chemical compound with the molecular formula C21H26N2O5S. It is a sulphonamide derivative and is commonly used in the pharmaceutical industry as a potential drug candidate for various medical conditions. The compound has been studied for its potential anti-inflammatory and anticancer properties. Its unique molecular structure and functional groups make it a promising candidate for further research and development. However, further studies are needed to fully understand its pharmacological properties and potential applications in medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 33456-68-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,5 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 33456-68:
(7*3)+(6*3)+(5*4)+(4*5)+(3*6)+(2*6)+(1*8)=117
117 % 10 = 7
So 33456-68-7 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N2O5S/c1-20(2)17-9-6-14(27-3)12-16(17)18(23)22(19(20)24)11-10-13-4-7-15(8-5-13)28(21,25)26/h4-9,12H,10-11H2,1-3H3,(H2,21,25,26)

33456-68-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]benzenesulfonamide

1.2 Other means of identification

Product number -
Other names EINECS 251-529-0

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:33456-68-7 SDS

33456-68-7Downstream Products

33456-68-7Relevant articles and documents

A preparation method of the midbody gliquidone (by machine translation)

-

Paragraph 0029; 0032-0037, (2019/10/04)

The present invention provides a preparation method of the midbody gliquidone, a one-step instead of the traditional two-step process, in order to 7 - methoxy - 2, 4, 4 - trimethyl - 1, 3 (2 H, 4 H) - isoquinoline diketone as the starting material, with 4 - (2 - aminoethyl) - benzene sulfonamide in the xylene solution of sodium hydroxide in addition, so as to directly produce 4 - (2 - (3, 4 - dihydro - 7 - methoxy - 4, 4' - dimethyl - 1, 3 - dioxo - 2 (1 H) - isoquinolyl) ethyl) benzene sulfonamide; to avoid the two-step in the reversible reaction, which significantly improves the product generation rate, in addition the reaction process is small dosage add sodium hydroxide, greatly reduce the alkali waste water output, to avoid polluting the environment. (by machine translation)

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors

Hill, James R.,Coll, Rebecca C.,Sue, Nancy,Reid, Janet C.,Dou, Jennifer,Holley, Caroline L.,Pelingon, Ruby,Dickinson, Joshua B.,Biden, Trevor J.,Schroder, Kate,Cooper, Matthew A.,Robertson, Avril A. B.

, p. 1449 - 1457 (2017/09/18)

Insulin-secretory sulfonylureas are widely used, cost-effective treatments for type 2 diabetes (T2D). However, pancreatic β-cells are continually depleted as T2D progresses, thereby rendering the sulfonylurea drug class ineffective in controlling glycaemia. Dysregulation of the innate immune system via activation of the NLRP3 inflammasome, and the consequent production of interleukin-1β, has been linked to pancreatic β-cell death and multiple inflammatory complications of T2D disease. One proposed strategy for treating T2D is the use of sulfonylurea insulin secretagogues that are also NLRP3 inhibitors. We report the synthesis and biological evaluation of nine sulfonylureas that inhibit NLRP3 activation in murine bone-marrow- derived macrophages in a potent, dose-dependent manner. Six of these compounds inhibited NLRP3 at nanomolar concentrations and can also stimulate insulin secretion from a murine pancreatic cell line (MIN6). These novel compounds possess unprecedented dual modes of action, paving the way for a new generation of sulfonylureas that may be useful as therapeutic candidates and/or tool compounds in T2D and its associated inflammatory complications.

Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes

Hill, Ronald A.,Rudra, Sonali,Peng, Bo,Roane, David S.,Bounds, Jeffrey K.,Zhang, Yang,Adloo, Ahmad,Lu, Tiansheng

, p. 2099 - 2113 (2007/10/03)

We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.

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