33458-93-4 Usage
Description
AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors. AH 6809 blocks the PGE2-induced accumulation of cAMP in COS cells transfected with the human EP2 receptor. It also blocks the accumulation of Ca2+ in Xenopus oocytes expressing the human EP1 receptor. In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent. In the mouse, AH 6809 has the highest affinity for the EP2 receptor, but also acts as a weak ligand at the murine EP1 and DP1 receptors. In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD2, but not PGI2, with an EC50 of about 5 x 10?5 M.
Uses
AH-6809 is a prostaglandin E2 receptor antagonist.
Biological Activity
Antagonist at prostaglandin EP 1 (pA 2 = 6.8 ) and EP 2 (K i = 350 nM) receptors. Also weakly inhibits DP receptors (pA 2 = 4.45).
References
1) Coleman in Prostaglandins and Related Substances: A Practical Approach; ILR Press, Oxford and Washington D.C. 1987, pg 267
Check Digit Verification of cas no
The CAS Registry Mumber 33458-93-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,4,5 and 8 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 33458-93:
(7*3)+(6*3)+(5*4)+(4*5)+(3*8)+(2*9)+(1*3)=124
124 % 10 = 4
So 33458-93-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)
