3346-68-7

Upstream product

• 23945-44-0 2,4-dihydroxypyrimidine-5-carboxylic acid 
• 23945-44-0 2,4-dihydroxypyrimidine-5-carboxylic acid 

Downstream Products

• 330784-47-9 avanafil 
• 28485-17-8 5-carbethoxyuracil 

Relevant academic research and scientific papers

Anti-tumor pyrimidine compounds and preparation method thereof

The invention belongs to the field of medicines and particularly relates to anti-tumor pyrimidine compounds and a preparation method thereof. The compounds belong to novel VEGFR (vascular endothelial growth factor receptor)-2 inhibitors and show good inhi

Atorvastatin that non-preparation method

The invention relates to a preparation method of avanafil and a new compound provided in a preparation process. According to the method, 5-uracil carboxylic acid or an ester thereof is taken as the raw material, and the avanafil meeting the clinical requirements can be synthesized at a relatively cost; besides, the preparation method is simple and convenient to operate, mild in reaction conditions, high in yield, low in cost, environmentally friendly and suitable for industrial large-scale production of the avanafil.

INHIBITORS OF JAK

The present invention is directed to compounds of formula (I) and tautomers and pharmaceutically acceptable salts thereof which are selective inhibitors of JAK. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition JAK activity, and methods to prevent or treat a number of conditions mediated at least in part by JAK activity.

INHIBITORS OF PROTEIN KINASES

The present invention is directed to compounds of formula (I)-(II) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

Herbicidally active substituted pyrimidine compounds and method of using same

Substituted pyrimidine compounds particularly useful as selective post-emergent herbicides are described for inhibiting the growth of and killing undesirable plants and weeds. The compounds hereof include 2,4-substituted pyrimidine-5-carboxylates having the general formula STR1 wherein X, Y and R represent specific types and classes of substituent groups. Especially preferred compounds in accordance with the invention include octyl 2,4-dichloropyrimidine-5-carboxylate, benzyl 2,4-dichloropyrimidine-5-carboxylate, allyl 2,4-dichloropyrimidine-5-carboxylate, ethyl 4-chloro-2-mercaptopyrimidine-5-carboxylate, butyl 2-chloro-4-di-n-propylaminopyrimidine-5-carboxylate. The compounds may be applied by conventional spray techniques at a dosage rate of from about 1/4 to 20 pounds per acre to good effect.