334636-18-9

Upstream product

• 334636-14-5 [1-(4-{2-[4-(2-benzyloxy-phenyl)-1H-indol-3-yl]-2-oxo-ethylcarbamoyl}-oxazol-2-yl)-2-methyl-propyl]-carbamic acid tert-butyl ester 
• 334636-11-2 2-{2-[4-(2-benzyloxy-phenyl)-1H-indol-3-yl]-2-oxo-ethyl}-isoindole-1,3-dione 
• 1026620-44-9 2-amino-1-[4-(2-benzyloxy-phenyl)-1H-indol-3-yl]-ethanone 
• 334636-16-7 4-(2-benzyloxy-phenyl)-3-({[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-oxazole-4-carbonyl]-amino}-acetyl)-indole-1-carboxylic acid methyl ester 

Downstream Products

• 377777-94-1 3-(2'-{(S)-1-[3-(3-Benzyloxycarbonyl-4-methoxy-phenyl)-propionylamino]-2-methyl-propyl}-[2,4']bioxazolyl-5-yl)-4-(2-benzyloxy-phenyl)-indole-1-carboxylic acid methyl ester 
• 377777-91-8 3-[2'-(1-tert-butoxycarbonylamino-2-methyl-propyl)-[2,4']bioxazolyl-5-yl]-4-[2-(2-methoxy-benzoyloxy)-phenyl]-indole-1-carboxylic acid methyl ester 
• 377777-90-7 3-[2'-(1-tert-butoxycarbonylamino-2-methyl-propyl)-[2,4']bioxazolyl-5-yl]-4-(2-hydroxy-phenyl)-indole-1-carboxylic acid methyl ester 
• 377777-93-0 3-[2'-((S)-1-Amino-2-methyl-propyl)-[2,4']bioxazolyl-5-yl]-4-(2-benzyloxy-phenyl)-indole-1-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Vilsmeier methodology for the synthesis of 3-(2-N-phthaloylacyl)indole derivatives, and its application to the synthesis of the GCDEF rings of diazonamide

The synthesis of the GCDEF fragment of diazonamide was achieved using a modified Vilsmeier procedure that allows ready access to 3-(2-N-phthaloylacyl)indole derivatives.