33468-84-7

Usage

Uses

Used in Pharmaceutical Industry:
3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine is used as a building block for the synthesis of biologically active molecules. Its unique structure allows it to be incorporated into the design of new drugs, potentially leading to the development of novel therapeutic agents for the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine is utilized as a component in the creation of pesticides. Its chemical properties make it a valuable asset in the development of effective and targeted pest control solutions.
Used in Medicinal Chemistry Research:
3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine serves as a research chemical, facilitating the study of structure-activity relationships of small molecules. This understanding is crucial for optimizing the potency, selectivity, and safety profiles of drug candidates, thereby advancing the field of medicinal chemistry.
Used in Disease Treatment Research:
3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine has been investigated for its potential application in the treatment of various diseases. Its unique chemical structure may offer new avenues for therapeutic intervention, contributing to the discovery of innovative treatments and improving patient outcomes.

InChI:InChI=1/C9H6F3N3/c10-9(11,12)7-5-14-8(15-7)6-2-1-3-13-4-6/h1-5H,(H,14,15)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 63920-62-7 3-(4-trifluoromethyl-1(3)H-imidazol-2-yl)-pyridine 1-oxide 

Relevant academic research and scientific papers

Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones

A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi

Synthesis and Cardiotonic Activity of Novel Biimidazoles

A series of substituted 2,2-bi-1H-imidazoles and related analogues was synthesized and evaluated for inotropic activity.Structure-activity relationship studies based on a nonclassical bioisosteric approach indicated the necessity of a cyano group on one o

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.