33468-84-7

Basic information

• Product Name: 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine
• Synonyms: 2-(3-Pyridyl)-4-(trifluoromethyl)imidazole;3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine;2-(3-Pyridinyl)-4-(trifluoromethyl)-1H-imidazole;MK-534
• CAS NO: 33468-84-7
• Molecular Formula: C9H6F3N3
• Molecular Weight: 213.16
• Mol File: 33468-84-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 228-229 °C
• Boiling Point: 371 °C at 760 mmHg
• Flash Point: 178.2 °C
• Appearance: /
• Density: 1.393
• Vapor Pressure: 2.26E-05mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine(33468-84-7)
• EPA Substance Registry System: 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine(33468-84-7)

Safety Data

• Hazardous Substances Data: 33468-84-7(Hazardous Substances Data)

Usage

General Description

3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine is a chemical compound with the molecular formula C8H5F3N4. It is a heterocyclic compound containing a trifluoromethyl group and an imidazole ring attached to a pyridine ring. 3-(4-Trifluoromethyl-1H-imidazol-2-yl)pyridine is primarily used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active molecules and pesticides. It has been studied for its potential application in the treatment of various diseases and as a potential tool in medicinal chemistry. Additionally, it is also used as a research chemical for studying the structure-activity relationships of small molecules.

InChI:InChI=1/C9H6F3N3/c10-9(11,12)7-5-14-8(15-7)6-2-1-3-13-4-6/h1-5H,(H,14,15)

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 63920-62-7 3-(4-trifluoromethyl-1(3)H-imidazol-2-yl)-pyridine 1-oxide 

Relevant articles and documents

Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones

A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.