33469-09-9

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
1H-Imidazole, 2-(4-nitrophenyl)-5-(trifluoromethyl)is used as a building block in organic synthesis for the creation of pharmaceuticals and agrochemicals. Its unique structure and properties contribute to the development of new compounds with potential therapeutic and pesticidal activities.
Used in Anti-Inflammatory Applications:
1H-Imidazole, 2-(4-nitrophenyl)-5-(trifluoromethyl)has been investigated for its potential use as an anti-inflammatory agent. Its ability to modulate inflammatory pathways and reduce inflammation makes it a promising candidate for the treatment of various inflammatory conditions.
Used in Anti-Cancer Applications:
1H-IMidazole, 2-(4-nitrophenyl)-5-(trifluoroMethyl)is also being studied for its potential as an anti-cancer agent. The trifluoromethyl group enhances its lipophilicity, allowing it to more effectively penetrate cell membranes and target cancer cells. Its potential to inhibit cancer cell growth and proliferation makes it a candidate for further research and development in oncology.
Used in Drug Design and Development:
Due to its enhanced lipophilicity and unique structural features, 1H-Imidazole, 2-(4-nitrophenyl)-5-(trifluoromethyl)is utilized in drug design and development. It serves as a valuable starting point for the creation of new drugs with improved pharmacokinetic properties and therapeutic efficacy.

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 33469-30-6 4-(5-(trifluoromethyl)-1H-imidazol-2-yl)aniline 
• 279250-92-9 2-(4-nitrophenyl)-4-cyano-1H-imidazole 
• 279251-11-5 2-(4-nitrophenyl)-1H-4-imidazolcarbaldehyde 

Relevant academic research and scientific papers

Discovery of novel 2-aryl-4-bis-amide imidazoles (ABAI) as anti-inflammatory agents for the treatment of inflammatory bowel diseases (IBD)

A series of 2-Aryl-4-Bis-amide Imidazoles (ABAI-1 to 30) were designed as anti-inflammatory agents. These compounds were synthesized and evaluated for the in vitro anti-inflammatory activities (inhibition of NO production and release of inflammatory cytok

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones

A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.