33469-10-2

Usage

Uses

Used in Pharmaceutical Research and Development:
BenzenaMine, N,N-diMethyl-4-[5-(trifluoroMethyl)-1H-iMidazol-2-y is used as a research compound for studying imidazole derivatives and their potential therapeutic applications. Its unique chemical structure allows for the exploration of various biological activities and interactions with target molecules.
Used in Chemical Production:
BenzenaMine, N,N-diMethyl-4-[5-(trifluoroMethyl)-1H-iMidazol-2-y may also be used in the production of certain types of chemicals or materials. Its specific properties and reactivity can contribute to the synthesis of various compounds and formulations in the chemical industry.

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 279250-93-0 2-(4-dimethylaminophenyl)-4-cyano-1H-imidazole 
• 279251-12-6 2-(4-dimethylaminophenyl)-1H-4-imidazolcarbaldehyde 

Relevant academic research and scientific papers

Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones

A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.