33469-16-8

Basic information

• Product Name: 1H-IMidazole, 2-(3,4-dichlorophenyl)-5-(trifluoroMethyl)-
• Synonyms: 2-(3,4-Dichlorophenyl)-5-(trifluoromethyl)-1H-imidazole;1H-IMidazole, 2-(3,4-dichlorophenyl)-5-(trifluoroMethyl)-
• CAS NO: 33469-16-8
• Molecular Formula: C10H5Cl2F3N2
• Molecular Weight: 281.0613096
• Mol File: 33469-16-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-IMidazole, 2-(3,4-dichlorophenyl)-5-(trifluoroMethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 2-(3,4-dichlorophenyl)-5-(trifluoroMethyl)-(33469-16-8)
• EPA Substance Registry System: 1H-IMidazole, 2-(3,4-dichlorophenyl)-5-(trifluoroMethyl)-(33469-16-8)

Safety Data

• Hazardous Substances Data: 33469-16-8(Hazardous Substances Data)

Usage

General Description

1H-Imidazole, 2-(3,4-dichlorophenyl)-5-(trifluoromethyl)- is a chemical compound with the molecular formula C9H5Cl2F3N2. It is a heterocyclic aromatic organic compound with a five-membered ring structure containing two nitrogen atoms. This chemical is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has potential applications in the development of new drugs and is also used in biochemical research and analysis. Its unique structure and properties make it a valuable tool in the advancement of various scientific and medical fields.

Relevant articles and documents

Trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni

4-Trifluoromethylimidazoles and 5-(4-pyridyl)-1,2,4-triazoles, new classes of xanthine oxidase inhibitors.

The syntheses of a number of 2-substituted 4-trifluoromethylimidazoles and 3-substituted 5-(4-pyridyl)-1,2,4-triazoles are described. The trifluoromethylimidazoles were prepared from 3,3-dibromo-1,1,1-trifluoroacetone after hydrolysis with aqueous sodium acetate solution and condensation with an aldehyde in the presence of ammonia. Basic hydrolysis of the trifluoromethyl group was found to provide a facile method for the synthesis of imidazole-4-carboxylic acids. In the imidazole series a 2-aryl substituent and a free imino group were required for xanthine oxidase inhibitory activity. The triazoles were obtained through the reaction of an aroylhydrazine and an imino ether followed by thermal ring closure of the intermediate acylamidrazone. As in the imidazole series, a free imino group is an absolute requirement for in vitro activity. Additional structure-activity relationships of these compounds are presented.