33469-18-0

Basic information

• Product Name: 2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole
• Synonyms: 2-p-tolyl-4-(trifluoromethyl)-1H-imidazole;2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole;1H-IMidazole, 2-(4-Methylphenyl)-5-(trifluoroMethyl)-;2-(4-methylphenyl)-5-(trifluoromethyl)-1H-Imidazole
• CAS NO: 33469-18-0
• Molecular Formula: C₁₁H₉F₃N₂
• Molecular Weight: 226.2
• Product Categories: Heterocycle
• Mol File: 33469-18-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 221-222 °C
• Boiling Point: 345.391 °C at 760 mmHg
• Flash Point: 162.687 °C
• Appearance: /
• Density: 1.284
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: 2-8°C
• PKA: 10.79±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole(33469-18-0)
• EPA Substance Registry System: 2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole(33469-18-0)

Safety Data

• Hazardous Substances Data: 33469-18-0(Hazardous Substances Data)

Usage

General Description

2-(4-Methylphenyl)-4-(trifluoromethyl)-1H-imidazole is a chemical compound that consists of an imidazole ring structure, a trifluoromethyl group, and a 4-methylphenyl ring. The imidazole ring is a five-membered planar ring, which includes two nitrogen atoms. The trifluoromethyl group adds to the compound's reactivity due to the highly electronegative fluorine atoms. The 4-methylphenyl, also known as para-tolyl group, is a derivative of phenyl with a methyl group attached to the fourth carbon atom. This chemical compound exhibits a complex structure and displays interesting chemical behaviors under various conditions. It is often used in scientific research and development.

InChI:InChI=1/C11H9F3N2/c1-7-2-4-8(5-3-7)10-15-6-9(16-10)11(12,13)14/h2-6H,1H3,(H,15,16)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 111269-38-6 1,1,1-trifluoro-3-(dimethylhydrazono)-2-propanone 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 

Downstream Products

• 279250-98-5 2-(p-tolyl)-4-cyano-1H-imidazole 
• 1250030-88-6 methyl 2-p-tolyl-1H-imidazole-5-carboxylate 

Relevant articles and documents

Discovery of novel 2-aryl-4-bis-amide imidazoles (ABAI) as anti-inflammatory agents for the treatment of inflammatory bowel diseases (IBD)

A series of 2-Aryl-4-Bis-amide Imidazoles (ABAI-1 to 30) were designed as anti-inflammatory agents. These compounds were synthesized and evaluated for the in vitro anti-inflammatory activities (inhibition of NO production and release of inflammatory cytok

Synthesis, structure, and neuroprotective properties of novel imidazolyl nitrones

A new series of imidazolyl nitrones spin traps has been synthesized and evaluated pharmacologically. The salient structural feature of these molecules is the presence of an imidazole moiety substituted by aromatic or heteroaromatic cycles. This connectivi

2-Pyrazinyl-trifluoromethylimidazoles and a method for their preparation

4(5)-Trifluoromethylimidazoles having optional substituents in the 1 and 2 positions are provided. The novel 4(5)-trifluoromethylimidazoles are prepared by reacting a 1,1-dihalo-3,3,3-trifluoroacetone compound with an appropriate carboxaldehyde and ammoni