334699-05-7Relevant academic research and scientific papers
Helical foldamer-catalyzed enantioselective 1,4-addition reaction of dialkyl malonates to cyclic enones
Umeno, Tomohiro,Ueda, Atsushi,Doi, Mitsunobu,Kato, Takuma,Oba, Makoto,Tanaka, Masakazu
, (2019)
The introduction of a five-membered ring α,α-disubstituted α-amino acid into L-Leu-based heptapeptides preferentially induced right-handed (P) helical structures. Using 5 ～ 20 mol% of a single helical foldamers-catalyst, enantioselective 1,4-addition reactions of dialkyl malonates to cycloalk-2-enones (5 ～ 7 rings) proceeded to give chiral 3-substituted cycloalkanones with 94 ～ 99% ee in moderate chemical yields, regardless of the ring size of substrates.
Enzyme-Promoted Direct Asymmetric Michael Reaction by Using Protease from Streptomyces griseus
Wu, Ling-Ling,Li, Ling-Po,Xiang, Yang,Guan, Zhi,He, Yan-Hong
, p. 2209 - 2214 (2017/07/24)
The direct asymmetric Michael addition of malonates and enones was promoted by protease from Streptomyces griseus for the first time. Yields of up to 84% with enantioselectivities of up to 98% enantiomeric excess (ee) were achieved under optimized conditi
Asymmetric Michael addition of malonates to enones catalyzed by a siloxy amino acid lithium salt
Yoshida, Masanori,Narita, Mao,Hirama, Keisuke,Hara, Shoji
supporting information; experimental part, p. 7297 - 7299 (2010/03/03)
Siloxy amino acid lithium salt, O-tert-butyldiphenylsilyl l-serine lithium salt, was found to be an effective catalyst for the asymmetric Michael addition reaction of malonates to enones.
