334704-83-5Relevant academic research and scientific papers
An expeditious construction of polycyclic ketals: Synthesis of fused seven-membered rings and substituted naphthalenes
Hanna, Issam,Michaut, Valérie,Ricard, Louis
, p. 231 - 234 (2001)
Treatment of allylic alcohols 5, easily prepared from dioxene and methoxyacetophenones, with 1-(trimethylsilyloxy)cyclopentene in the presence of a catalytic amount of TMSOTf in acetonitrile, afforded a polycyclic acetal 6 by domino nucleophilic substitution, annulation and intramolecular Friedel-Crafts alkylation reaction sequence. Acid-mediated cleavage of the acetal moiety led to fused seven-membered carbocyclic rings or to substituted naphthalenes.
