334709-06-7Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
Abbasi,Irshad,Aziz-ur-Rehman,Siddiqui,Junaid,Shah,Ashraf
, p. 596 - 603 (2020)
Four benzamide derivatives (5a, 5b, 8a, 8b) bearing heterocyclic furan and piperazine ring have been synthesized and evaluated for enzyme inhibition and hemolytic activity. Initial 4-(chloromethyl)benzoyl chloride (1) and 3-(chloromethyl)benzoyl chloride
Chemoselective reductive nucleophilic addition to tertiary amides, secondary amides, and N-methoxyamides
Nakajima, Minami,Oda, Yukiko,Wada, Takamasa,Minamikawa, Ryo,Shirokane, Kenji,Sato, Takaaki,Chida, Noritaka
supporting information, p. 17565 - 17571 (2015/02/19)
As the complexity of targeted molecules increases in modern organic synthesis, chemoselectivity is recognized as an important factor in the development of new methodologies. Chemoselective nucleophilic addition to amide car-bonyl centers is a challenge because classical methods require harsh reaction conditions to overcome the poor elec-trophilicity of the amide carbonyl group. We have successfully developed a reductive nucleophilic addition of mild nu-cleophiles to tertiary amides, secondary amides, and N-methoxyamides that uses the Schwartz reagent [Cp2ZrHCl]. The reaction took place in a highly chemoselective fashion in the presence of a variety of sensitive functional groups, such as methyl esters, which conventionally require protection prior to nucleophilic addition. The reaction will be applicable to the concise synthesis of complex natural alkaloids from readily available amide groups.
Magnetic CoFe2O4 nanoparticle immobilized N-propyl diethylenetriamine sulfamic acid as an efficient and recyclable catalyst for the synthesis of amides via the Ritter reaction
Zhao, Xiao-Na,Hu, Hai-Chuan,Zhang, Fu-Jun,Zhang, Zhan-Hui
, p. 258 - 265 (2014/07/08)
A magnetic CoFe2O4 nanoparticle immobilized diamine-N-sulfamic acid (CoFe2O4@SiO2-DASA) was synthesized and used as efficient heterogeneous catalyst for the synthesis of amides via the Ritter reaction under solvent-free conditions. The magnetic nanocatalyst could be readily recovered by applying an external magnet and recycled several times without considerable loss of its catalytic activity.
