334757-10-7Relevant academic research and scientific papers
Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand
Macchia, Bruno,Cervetto, Luigi,Demontis, Gian Carlo,Domiano, Paolo,Longoni, Biancamaria,Macchia, Marco,Minutolo, Filippo,Orlandini, Elisabetta,Ortore, Gabriella,Papi, Chiara
, p. 223 - 226 (2007/10/03)
The synthesis of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine 1, a potent and selective D4 dopaminergic ligand, was performed. The 3-(3,4-dimethylphenyl)-1-propylpiperidine with the R configuration showed an affinity for the D4 receptors 6-fold higher than the corresponding enantiomer with the S configuration. Furthermore, the (R)-1 enantiomer proved to be highly selective for D4 receptors with respect to D2-D3 receptors, with a Ki ratio higher than 25,000, while the (S)-1 enantiomer was about 100-fold less selective than the (R)-1 one.
