Basic information

Product Name: 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
Synonyms: 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one;Gisadenafil;UK 369003;5-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one
CAS NO:334826-98-1
Molecular Formula: C₂₃H₃₃N₇O₅S
Molecular Weight: 519.62
EINECS: N/A
Product Categories: N/A
Mol File: 334826-98-1.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 701.3±70.0 °C(Predicted)
Flash Point: N/A
Appearance: /
Density: 1.41
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
PKA: 6.91±0.10(Predicted)
CAS DataBase Reference: 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one(CAS DataBase Reference)
NIST Chemistry Reference: 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one(334826-98-1)
EPA Substance Registry System: 5-[2-Ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)pyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one(334826-98-1)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 334826-98-1(Hazardous Substances Data)

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SDS
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334826-98-1 Usage

Uses

Used in Oncology:
E-7050 is utilized as an anti-cancer agent for its ability to inhibit the activity of key receptor tyrosine kinases that are often implicated in tumor growth and angiogenesis. Its multi-targeted approach makes it a versatile candidate for treating a range of cancers.
Used in Clinical Trials:
E-7050 is being evaluated in clinical trials to assess its safety and efficacy in treating specific types of cancer, such as non-small cell lung cancer and other solid tumors. The trials aim to determine the optimal dosage and treatment regimens for patients.
Used in Drug Development for Targeted Therapies:
As a small molecule inhibitor with the capacity to target multiple receptor tyrosine kinases, E-7050 is a valuable asset in the development of targeted cancer therapies. Its potential to disrupt the signaling pathways that drive tumor growth and blood supply makes it a promising candidate for further research and development in oncology.
Used in Combination Therapies:
Given its mechanism of action, E-7050 may also be used in combination with other cancer treatments to enhance their effectiveness or overcome resistance. The synergistic effects of combining E-7050 with existing therapies could provide improved outcomes for patients with cancer.
Used in Pharmaceutical Research:
E-7050 serves as a model compound for the development of new drugs targeting receptor tyrosine kinases. Its structure and activity provide insights into the design of future generations of anti-cancer agents, potentially leading to the discovery of more effective and selective treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 334826-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,4,8,2 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 334826-98:
(8*3)+(7*3)+(6*4)+(5*8)+(4*2)+(3*6)+(2*9)+(1*8)=161
161 % 10 = 1
So 334826-98-1 is a valid CAS Registry Number.

334826-98-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	5-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-4H-pyrazolo[4,3-d]pyrimidin-7-one

1.2 Other means of identification

Product number	-
Other names	UNII-S6G4R7DI1C

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:334826-98-1 SDS

334826-98-1Upstream product

334826-98-1Downstream Products

334827-98-4 UK-369,003-26

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