334829-66-2

Usage

Uses

Used in Anticancer Applications:
D,L-SULFORAPHANE N-ACETYL-L-CYSTEINE is used as an antitumor agent in the pharmaceutical industry. It is particularly effective against various types of cancer due to its ability to induce phase 2 detoxification enzymes, which help neutralize and eliminate cancer-causing agents from the body.
Used in Detoxification Processes:
In the healthcare industry, D,L-SULFORAPHANE N-ACETYL-L-CYSTEINE is used to support the body's natural detoxification processes. By inducing phase 2 detoxification enzymes, it helps the body eliminate harmful substances and reduce the risk of developing chronic diseases, including cancer.
Used in Dietary Supplements:
D,L-SULFORAPHANE N-ACETYL-L-CYSTEINE is also used in the dietary supplement industry as an ingredient in products designed to promote overall health and well-being. These supplements may target specific health concerns, such as cancer prevention, or provide general support for the body's detoxification processes.
Used in Research and Development:
In the scientific research field, D,L-SULFORAPHANE N-ACETYL-L-CYSTEINE is used as a key compound in the study of cancer biology, detoxification mechanisms, and the development of novel therapeutic strategies for various diseases. Its unique properties make it an important tool for understanding the complex interactions between dietary components and human health.

Upstream product

• 4478-93-7 D,L-sulforaphane 
• 616-91-1 N-acetylcystein 
• 52096-68-1 2-<2-(Methylthio)butyl>-1H-isoindole-1,3(2H)-dione 
• 4430-36-8 erucin 
• 55021-77-7 4-(methylthio)-1-butylamine 

Relevant academic research and scientific papers

Discovery of a crystalline sulforaphane analog with good solid-state stability and engagement of the Nrf2 pathway in vitro and in vivo

The antioxidant natural product sulforaphane (SFN) is an oil with poor aqueous and thermal stability. Recent work with SFN has sought to optimize methods of formulation for oral and topical administration. Herein we report the design of new analogs of SFN with the goal of improving stability and drug-like properties. Lead compounds were selected based on potency in a cellular screen and physicochemical properties. Among these, 12 had good aqueous solubility, permeability and long-term solid-state stability at 23 °C. Compound 12 also displayed comparable or better efficacy in cellular assays relative to SFN and had in vivo activity in a mouse cigarette smoke challenge model of acute oxidative stress.

Synthesis of isothiocyanate-derived mercapturic acids

Twelve mercapturic acids derived from saturated and unsaturated aliphatic and aromatic isothiocyanates were synthesised, by adding isothiocyanate to a solution of N-acetyl-L-cysteine and sodium bicarbonate, in a typical yield of 77%. Isothiocyanates were synthesised first by adding the corresponding alkyl bromide to phthalimide potassium salt. The obtained N-alkyl-phthalimide was hydrazinolysed yielding the alkyl amine, which subsequently was reacted with thiophosgene yielding the isothiocyanate with an overall yield of 16%. Mercapturic acids in urine can serve as a biomarker of intake to determine the health promoting potential of isothiocyanates present in cruciferous vegetables.