334830-72-7Relevant academic research and scientific papers
The synthesis of pseudomycin C′ via a novel acid promoted side-chain deacylation of pseudomycin A
Rodriguez, Michael J.,Belvo, Matthew,Morris, Robert,Zeckner, Douglas J.,Current, William L.,Sachs, Roberta K.,Zweifel, Mark J.
, p. 161 - 164 (2007/10/03)
The γ hydroxyl present in the aliphatic side chain of the natural products pseudomycin A and C′ provided a unique handle for the pH dependent side-chain deacylation. Low pH reaction conditions were used to cleave the side chain with minimal degradation of the peptide core. The pseudomycin nucleus intermediate obtained from the deacylation of pseudomycin A was pivotal in the synthesis of novel side-chain analogues. A practical synthesis of a minor fermentation factor pseudomycin C′ and related analogues is reported.
