334932-58-0Relevant academic research and scientific papers
Synthesis of 1,2-dihydro-1,3-diaza-2λ5,4λ5-2,4- diphosphorine 2-oxides
Andújar, Carmen M,álvarez, Isidro Pérez,Ortiz, Fernando López
, p. 2569 - 2575 (2007/10/03)
The reaction of lithium (N-diphenylphosphoryl)phosphazenes with nitriles afforded 1,2-dihydro-1,3-diaza-2λ5,4λ5-2,4- diphosphorine 2-oxides through a C-regioselective addition to the cyano linkage followed by in situ cyclocondensation. The new heterocycles were designed to mimic thymine and are promising chemotherapeutic anticancer agents. As an exception, for p-nitrobenzonitrile a SNAr reaction was exclusively observed with the nucleophile entering in the ortho position of the nitro substituent in a process directed by the strong electron withdrawing effect of the NO2 group.
Stereoselective Synthesis of 1,2,5,6-Tetrahydro 1,3-Oxaza-4-phospha-2-phosphorine 2-Oxides through Reaction of P-Diphenyl(alkyl) (N-diphenylphosphoryl)phosphazenes with Aldehydes and Ketones
Perez, Emma Peralta,Ahrens, Birte,Davidson, Matthew G.,Raithby, Paul R.,Teat, Simon J.,Alvarez, Isidro Perez,Ortiz, Fernando Lopez
, p. 275 - 277 (2007/10/03)
Novel 1,2,5,6-tetrahydro 1,3-oxaza-4-phospha-2-phosphorine 2-oxides have been synthesised stereoselectively through addition of aldehydes and ketones to lithiated (N-diphenylphosphoryl)phosphazenes.
