334952-79-3Relevant academic research and scientific papers
Guanylpiperidine peptidomimetics: Potent and selective bis-cation inhibitors of factor Xa
Tamura, Susan Y.,Levy, Odile E.,Uong, Theresa H.,Reiner, John E.,Goldman, Erick A.,Ho, Jonathan Z.,Cohen, Cheryl R.,Bergum, Peter W.,Nutt, Ruth F.,Brunck, Terence K.,Semple, J. Edward
, p. 745 - 749 (2007/10/03)
A novel series of rigid P3-guanylpiperidine peptide mimics 3-14 was designed as potential factor Xa and prothrombinase inhibitors. Incorporation into a P2-gly-P1-argininal motif led to highly potent and selective inhibitors. The synthesis and biological activities of these derivatives are reported herein. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.
