334969-04-9Relevant academic research and scientific papers
Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl) phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents
Sharma, Vedula M.,Seshu, K. V. Adi,Sekhar, V. Chandra,Madan, Sachin,Vishnu,Babu, P. Aravind,Krishna, C. Vamsee,Sreenu,Krishna, V. Ravi,Venkateswarlu,Rajagopal, Sriram,Ajaykumar,Kumar, T. Sravan
, p. 67 - 71 (2007/10/03)
A new series of [4-(2-phenylethenesulfonylmethyl)phenyl]quinazolin-4-yl- amines was prepared and tested for its in vitro cytotoxic activity against a panel of 12 human cancer cell lines. Compounds 9, 15, 24 and 31 showed good in vitro activity and were further tested for their in vivo efficacy in the HT-29 human colon adeno carcinoma xenograft model. Compound 9 exhibited promising activity in this model. Dose-response studies for this compound against HT-29 human colon adeno carcinoma xenografts at 100, 200 and 400 mg/kg doses were performed.
(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
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, (2008/06/13)
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a
