334972-33-7Relevant academic research and scientific papers
High-pressure synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines
Poulsen, Sally-Ann,Young, David J.,Quinn, Ronald J.
, p. 191 - 193 (2001)
The synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines has been performed by aromatic nucleophilic substitution of 4-amino-6-chloro-1-phenylpyrazolo[3,4-d]pyrimidine under conditions of high pressure at ambient temperature. Conventional synthetic conditions (reflux at atmospheric pressure) were unsuccessful. The S enantiomer 11 displayed higher affinity and selectivity for the adenosine A1 receptor than the R enantiomer 12.
